Drugs online research references
Pharmacol Biochem Behav. 1981 Jun;14(6):823-6.
Effects of nortriptyline treatment on learned helplessness in the rat.
Telner JI, Singhal RL.
Using an escape delay procedure previously shown to elicit behavioral deficits in mice exposed to uncontrollable shock, rats treated with inescapable but not escapable shock or no shock displayed comparable interference effects when tested in a two-way shuttle box 24 hr later. Treatment with 12.5 mg/kg nortriptyline for 4 or 6 days counteracted the escape deficits produced by inescapable shock while the 0 or 2 day administration regimens were without any appreciable effect. The finding that interference effects produced by inescapable shock were sensitive to sub-acute but not acute drug administration supports the utility of the learned helplessness model in evaluating potential antidepressant agents in experimental animals.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7196048&dopt=Abstract
J Clin Psychopharmacol. 1988 Jun;8(3):204-7.
Nortriptyline in the treatment of panic disorder and agoraphobia with panic attacks.
Munjack DJ, Usigli R, Zulueta A, Crocker B, Adatia N, Buckwalter JG, Baltazar P, Kurvink W, Inglove H, Kelly R, et al.
Department of Psychiatry, Los Angeles County-University of Southern California Medical Center 90033.
Thirty-four consecutive patients with panic disorder or agoraphobia with panic attacks were treated with nortriptyline at the LAC-USC Medical Center's Anxiety Disorders Clinic. Fourteen (67%) of the 21 completers totally lost their panic attacks, five (24%) showed partial improvement, and two (10%) showed no improvement. The relationship of treatment outcome to pretreatment and posttreatment measures of depression is discussed, in addition to the potential role of nortriptyline in treating panic attacks in clinical practice.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3379145&dopt=Abstract
Clin Chem. 1983 Feb;29(2):314-8.
Determination of the antidepressants maprotiline and amoxapine, and their metabolites, in plasma by liquid chromatography.
Wong SH, Waugh SW.
Maprotiline, amoxapine, and their metabolites were determined in plasma by three separate procedures, each of which involves a three-step extraction followed by reversed-phase separations. Amoxapine, maprotiline, and N-desmethylmaprotiline can be measured with use of a conventional C-18 column with 10% carbon load, but analyses for 7- and 8-hydroxyamoxapines require a small (5-microns) particle size, high carbon load, 20% C-18 column with 0.2 mol/L phosphate as mobile phase. Within-run and day-to-day CVs were 5% and 8%, respectively. Peak-height ratios were linearly correlated with concentrations between 0 and 400 micrograms/L. Detection limits ranged from 1 to 3 ng. Interference studies indicated that nortriptyline co-elutes with maprotiline. Assays of patients' plasma showed substantial amounts of these drugs and most of their metabolites, but only trace amounts of 7-hydroxyamoxapine.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6821936&dopt=Abstract
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