Drugs online research references
Therapie. 1992 Jan-Feb;47(1):41-5.
[Comparative study of two techniques for the determination of amitriptyline and nortriptyline: EMIT and gas chromatography]
[Article in French]
Vandel S, Vincent F, Prudhon F, Nezelof S, Bonin B, Bertschy G.
Laboratoire de Pharmacologie Clinique, CHU Minjoz, Besancon.
Amitriptyline and nortriptyline plasma level results obtained with gas chromatography and enzyme immunoassay were compared in 46 patients. The limits and problems with Emit measurement are discussed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1523593&dopt=Abstract
Ther Drug Monit. 1982;4(2):201-8.
Further considerations of the "single-point single-dose" method to estimate individual maintenance dosage requirements.
Unadkat JD, Rowland M.
The "single-point, single-dose" method for predicting individual maintenance dosage is examined. Data available in the literature on nortriptyline is used to illustrate the method. Optimal use of the method requires knowledge of the pharmacokinetics, especially the elimination rate constant, within the patient population requiring the drug. The method is applicable to intravenous and extravascular administration, when absorption is rapid relative to elimination, for those drugs whose disposition kinetics can be described by a linear one-compartment model. As a reasonable approximation, the optimal sampling time after the single test dose is 1.5 times the population half-life. Error in chemical analysis needs to be considered when applying the method. One method of evaluating the prediction and subsequent adjustment of dosage is discussed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7101388&dopt=Abstract
J Anal Toxicol. 1993 Mar-Apr;17(2):93-8.
The use of bone marrow in the study of postmortem redistribution of nortriptyline.
Winek CL, Morris EM, Wahba WW.
Allegheny County Department of Laboratories, Pittsburgh, PA 15219.
Thirty-two New Zealand Albino rabbits (1.5-2.0 kg) were dosed on a daily basis with 20 mg/kg nortriptyline (NT) prior to feeding for a period of five days. On the fifth day of dosing, the animals were sacrificed approximately 1.5 h after the final dose. A comparison was made of nortriptyline concentrations in the blood and bone marrow at the time of sacrifice, and between bone marrow collected at the time of sacrifice and bone marrow collected at 2, 4, 6, 12, 24, 36, and 48 h after sacrifice. The results indicate that a linear relationship exists between blood and bone marrow NT concentrations, with an average marrow-to-blood ratio of 29.98 +/- 3.91 and a correlation coefficient of 0.956. Additionally, there was no significant difference (p > 0.05) observed between NT concentrations in bone marrow at the time of sacrifice and its concentration up to 24 h after sacrifice. The results indicate that bone marrow may be used to predict blood concentrations of NT up to 24 h after death when a suitable blood sample is not available.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8492574&dopt=Abstract
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