Drugs online research references
Encephale. 1986 Jul-Aug;12(4):143-8.
[Pharmacogenetics of antidepressant metabolism. Value of the debrisoquin test]
[Article in French]
Baumann P.
The drug monitoring of antidepressants in blood plasma has revealed considerable interindividual differences in steady-state levels. For some compounds recent results strongly suggest that this phenomenon finds an explanation in genetic differences in the metabolism of the drugs by monooxygenases (cytochrome P-450) in the liver. Thus, a genetic deficiency has been described in 5-10% of the European population in the metabolism of debrisoquine and sparteine. Clinical experience shows that the separation of subjects into extensive metabolizers (EM) and poor metabolizers (PM) is also valid for drugs of interest in psychiatry, such as some betablockers and antidepressants like amitriptyline, nortriptyline and desipramine. Actually, PMs of debrisoquine may develop excessively high levels of these antidepressants in blood during the treatment. On the other hand, it is probable that, at least, one oxidative pathway of maprotiline belongs to the genetic polymorphism of debrisoquine, but a deficiency in the metabolism of this test substance does not necessarily mean high levels of maprotiline. Today's clinical experience shows that, in some cases, PMs of debrisoquine do not respond to a treatment with nortriptyline. However, this has not been demonstrated for amitriptyline. It is predicted that pharmacogenetic tests will find their place in psychopharmacotherapy, especially for subjects candidates for a long-term treatment or susceptible to suffer from side effects. However, the validity of the test remains to be demonstrated for other drugs, like benzodiazepines and neuroleptics, but also in the case of patients suffering from organic diseases or under treatment with potential competitors.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3792273&dopt=Abstract
Pharmacol Biochem Behav. 1985 Feb;22(2):261-4.
The acute effects of antidepressant drugs on the performance of conditioned avoidance behavior in rats.
Lucki I, Nobler MS.
The effects of acute administration of 10 different antidepressant drugs were examined on the performance of a two-way conditioned avoidance response in rats. The antidepressant drugs impaired avoidance behavior by decreasing avoidance responding and increasing the number of escape failures. The order of effectiveness for increasing overall response latency at a common dose of 10 mg/kg was: desipramine, maprotiline, protriptyline, (+) oxaprotiline, nortriptyline, imipramine, amitriptyline, (-) oxaprotiline, fluoxetine, and chlorimipramine. Avoidance behavior was impaired most by those antidepressant drugs that are also potent inhibitors of norepinephrine uptake.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3983218&dopt=Abstract
Arch Toxicol. 1987 Aug;60(6):467-9.
The effect of a lipid suspension on amitriptyline disposition.
Minton NA, Goode AG, Henry JA.
Poisons Unit, Guy's Hospital, London, UK.
A 5-h infusion of a lipid suspension or saline was given on separate occasions to four healthy volunteers taking amitriptyline. Mean plasma levels of amitriptyline plus nortriptyline were 14% higher at the end of the lipid infusion but the difference was not statistically significant. Infusion of a lipid suspension is unlikely to materially affect the severity of amitriptyline intoxication.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3662823&dopt=Abstract
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Wellstreet online pharmacy for click-order prescription medications ||
Altace Online Pharmacy ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Insurance plans and information ||
Insurance policies for all purposes ||
Antibiotics and prescription medications online literature ||