Drugs online research references
Arch Immunol Ther Exp (Warsz). 1975;23(6):787-94.
Influence of some antidepressant drugs on the circulatory system: II. Action of amitriptyline and nortriptyline on basic circulatory parameters.
Banaszkiewicz W, Grzymislawska I, Mrozikiewica A.
Amitriptyline and nortriptyline in doses higher than 0.5 mg/kg exert a hypotensive action, and doses of less than 0-5 mg/kg have no characteristic effect on blood pressure. Both drugs diminished amplitude of cardiac contractions in situ in experimental animals. Low doses increased frequency and amplitude of respirations, and higher doses paralyzed respiratory function. Animals died as a result of paralysis of the respiratory center. In decapitated animals both drugs exhibited activity similar to that in animals with intact central nervous system, but their hypotensive effect was less pronounced. Blockade of the sympathetic and parasympathetic systems and of vegetative ganglia had no influence on the action of amitriptyline and nortriptyline on blood pressure. In low doses both amitriptyline and nortriptyline potentiated, and in high doses weakened the hypertensive effect of noradrenaline.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1220630&dopt=Abstract
Clin Pharmacol Ther. 1983 Oct;34(4):516-20.
Amitriptyline metabolism: relationship to polymorphic debrisoquine hydroxylation.
Mellstrom B, Bertilsson L, Lou YC, Sawe J, Sjoqvist F.
Amitriptyline AT demethylation to nortriptyline NT was determined in nine healthy subjects who had been phenotyped with respect to debrisoquine D hydroxylation capacity. AT demethylation was calculated from the ratio between the plasma AUCs of NT after single oral doses of AT and NT. Plasma clearance of AT by demethylation did not correlate with the ratio between D and 4-hydroxy-D in urine (rs = -0.55).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6617075&dopt=Abstract
J Affect Disord. 1980 Mar;2(1):27-35.
Symptoms as predictors of response to amitriptyline and nortriptyline -- the plasma level variable.
Coryell W, Ziegler VE, Biggs JT.
Data collected to define therapeutic plasma levels for amitriptyline and nortriptyline were re-analyzed to test endogenous and non-endogenous symptoms as response predictors while controlling for plasma level variable. The selection criteria limited the range of historical predictors. Initial symptom quality was not predictive of outcome for the entire group of 44 patients or for the 27 with therapeutic plasma levels. Delusions were not associated with poor outcome. The authors conclude that historical components of the endogenous--non-endogenous distinction (e.g., premorbid personality, stability of symptoms over time, quality of remissions) may be more important as response predictors.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6448878&dopt=Abstract
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