Drugs online research references
J Chromatogr. 1992 Jan 3;573(1):141-5.
Sensitive method for the quantitation of nortriptyline and 10-hydroxynortriptyline in human plasma by capillary gas chromatography with electron-capture detection.
Anliker SL, Hamilton M, Bopp RJ, Goldberg MJ.
Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN 46285.
A method for the determination of nortriptyline and 10-hydroxynortriptyline concentrations in human plasma by capillary gas chromatography with electron-capture detection is described. The procedure requires 1.0 ml of plasma and uses maprotiline as an internal standard. The compounds are extracted from alkalinized plasma with hexane-2-butanol (98:2) and back-extracted into hydrochloric acid. The acid solution is then made basic and the compounds are re-extracted into n-butyl chloride. The extract is evaporated to dryness, derivatized with heptafluorobutyric anhydride, and analyzed by gas chromatography on a fused-silica capillary column coated with phenylmethyl silicone. The calibration curves for nortriptyline and 10-hydroxynortriptyline are linear in the ranges 3-40 and 7-90 micrograms/l, respectively, with coefficients of variation for within-day and between-day precision of less than 12%. The quantitation limits for nortriptyline and 10-hydroxynortriptyline are 1 and 3 micrograms/l, respectively. This procedure was used to analyze more than 1400 samples following sub-therapeutic doses of nortriptyline in human subjects. The assay was sufficiently sensitive for use in pharmacokinetic analysis.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1564093&dopt=Abstract
J Chromatogr B Biomed Appl. 1994 May 13;655(2):213-23.
Identification and quantitation of drugs of abuse in urine using the generalized rank annihilation method of curve resolution.
Li S, Gemperline PJ, Briley K, Kazmierczak S.
Department of Chemistry, East Carolina University, Greenville, NC 27858.
A rapid analytical method which is of practical use for the identification and quantitation of drugs of abuse in urine using HPLC with a diode-array detection is described. Because the method utilizes mathematical resolution of partially resolved peaks, greatly simplified sample preparation procedures and very short run times can be used. The generalized rank annihilation method (GRAM) is used to eliminate response due to unknown background peaks and separate partially resolved peaks. An optimized gradient elution program was found for which morphine, phenylpropanolamine, ephedrine, benzoylecgonine, lidocaine, cocaine, diphenhydramine, nortriptyline, norpropoxyphene, nordiazepam, codeine, D-amphetamine, meperidine, and amitriptyline elute from the HPLC column in less than 8.5 min. A commercially available system for HPLC analysis of drugs of abuse is currently available, however, the commercially available system takes 21 min to complete its analysis. Two modified sample pre-treatment methods were also developed to simplify sample treatment procedures substantially. In this paper, The GRAM technique is shown to be extremely powerful in identifying drugs of abuse from large overlapping peaks.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8081467&dopt=Abstract
Cesk Psychiatr. 1993 Jun;89(3):163-5.
[Indications for antidepressive agents in relation to diseases of the cardiovascular system]
[Article in Czech]
Tikal K, Hrabankova M.
Psychiatricka lecebna Kosmonosy.
Antidepressants, in particular tricyclic ones (TCA), and inhibitors of monoaminooxidase (IMAO) exert a number of undesirable cardiovascular effects. TCA and IMAO frequently cause postural hypotension (PH). IMAO administration is associated with the risk of hypertensive crisis. TCA raises the heart rate and can cause abnormalities in the conduction of the cardiac excitation. TCA are contraindicated after myocardial infarction and are the cause of death after overdosage. When PH is undesirable, in hypertension and cardiac insufficiency the following safe antidepressants are recommended: nortriptyline, mianserine, trazodone and viloxazine. In abnormalities of conduction of the cardiac excitation and after myocardial infarction only mianserine, trazodione and viloxazine are recommended. With regard to cardiovascular toxicity, antidepressants from the series of selective inhibitors of serotonin reabsorption are very promising: fluvoxamine, fluoxetine, citalopram, paroxetine and sertraline. The same applies also to the reversible IMAO type A moclobemide.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8353831&dopt=Abstract
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