Drugs online research references
Br J Clin Pharmacol. 1983 Nov;16(5):549-52.
Serum protein binding of propylthiouracil.
Kampmann JP, Molholm Hansen JE.
Serum protein binding of propylthiouracil (PTU) was measured by ultrafiltration in healthy and hyperthyroid patients. The serum protein binding in 12 euthyroid subjects was 76.2 +/- 1.2% (mean +/- s.d.), not significantly different from the values in 10 hyperthyroid patients: 76.6 +/- 1.3% Binding was unaffected by incubation time and temperatures between 25 and 37 degrees C, but increased from 76.5 to 79.1% when pH changed from 7.4 to 7.9. PTU is predominantly bound to albumin with two classes of binding groups with different number of binding sites and affinity. Displacement experiments showed interaction with acetylsalicylic acid, warfarin and phenylbutazone, but not with antipyrine and nortriptyline or other basic drugs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6639841&dopt=Abstract
J Affect Disord. 1985 Jan-Feb;8(1):47-53.
Cost-benefit analysis of prospective pharmacokinetic dosing of nortriptyline in depressed inpatients.
Simmons SA, Perry PJ, Rickert ED, Browne JL.
A retrospective chart review was conducted on depressed inpatients to determine the economic impact of prospective pharmacokinetic dosing vs. empirical dosing of tricyclic antidepressants. The benefit/cost ratio of 2.5 indicated that the benefits of prospective dosing more than doubled the cost. The prospectively dose patients were discharged significantly earlier, i.e. 6.1 days than the empirically dosed patients and they also returned to work significantly earlier, i.e. 55.4 days than the control group.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3156911&dopt=Abstract
J Pharm Sci. 1975 Jun;64(6):1036-7.
Comparison of observed and predicted bioavailability of nortriptyline in humans following oral administration.
Gibaldi M.
The first-pass equation based on the dose, hepatic blood flow, and total area under the plasma level-time curve after oral administration was used retrospectively to predict the bioavailability of nortriptyline after oral administration of 1 mg/kg-single oral doses to monozygotic and dizygotic twin pairs. The predicted values of bioavailability ranged from 45 to 85%, consistent with experimentally derived estimates of nortriptyline availability.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1133723&dopt=Abstract
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