Drugs online research references
Canine cataplexy is preferentially controlled by adrenergic mechanisms: evidence using monoamine selective uptake inhibitors and release enhancers.
To the pharmacological profile of maprotiline.
Serum protein binding of propylthiouracil.
Comparison of observed and predicted first-pass metabolism of nortriptyline in humans.
Plasma levels, psychophysiological variables, and clinical response to amitriptyline.
Radioimmunoassay for psychotropic drugs II: synthesis and properties of haptens for tricyclic antidepressants.
Sensitive method for the quantitation of nortriptyline and 10-hydroxynortriptyline in human plasma by capillary gas chromatography with electron-capture detection.
Studies of excretion in rabbit milk after administration of carbon-14 labelled amitriptyline and nortriptyline.
Lack of interaction of ranitidine with amitriptyline.
Influence of some antidepressant drugs on the circulatory system: II. Action of amitriptyline and nortriptyline on basic circulatory parameters.
Tricyclic antidepressants and acid secretory response of rabbit gastric cells.
Urinary MHPG and clinical response to amitriptyline in depressed patients.
Influence of cooling on the responsiveness of rat isolated anococcygeus muscle to noradrenaline.
Prospective study of scheduled withdrawal from nortriptyline in children and adolescents.
Decreased tyramine sensitivity after discontinuation of amitriptyline therapy. An index of pharmacodynamic half-life.
New evidence of serotonin-deficient depressions.
Effect of various antidepressant drugs on the spontaneous firing rate of locus coeruleus and dorsal raphe neurons of the rat.
Proceedings: Age and sex specificity of organ distribution and metabolism of chlorprothixene and nortriptyline in the rat
An external quality-control scheme for tricyclic antidepressants.
Pharmacogenetics of antidepressant metabolism. Value of the debrisoquin test
Application of expert systems analysis to interpretation of fatal cases involving amitriptyline.
Amitriptyline-induced loss of tight junction integrity in a human endothelial--smooth muscle cell bi-layer model.
Comparative study of two techniques for the determination of amitriptyline and nortriptyline: EMIT and gas chromatography
The effect of toxic and therapeutic doses of tricyclic antidepressant drugs on intracardiac conduction.
Use of potentiation of thyrotrophin releasing hormone (TRH)-induced hyperthermia as a test for screening antidepressants which activate alpha-adrenoceptor systems.
The influence of ethanol on the distribution of amitriptyline and nortriptyline in rats.
Plasma-serum differences in the assessment of tricyclic antidepressant blood levels.
Reliable routine method for the determination of plasma amitriptyline and nortriptyline by gas chromatography.
Effects of tricyclic antidepressant drugs on the electrophysiological properties of drug Purkinje fibers.
Effects of nortriptyline treatment on learned helplessness in the rat.
Nortriptyline in the treatment of ADHD: a chart review of 58 cases.
Plasma prolactin during treatment with nortriptyline.
Treatment of depression with tricyclic drugs--pharmacokinetic and pharmacodynamic aspects.
Isomers of 10-hydroxynortriptyline in geriatric depression.
High affinity binding of tricyclic antidepressants to histamine H1-receptors: fact and artifact.
Results compared for tricyclic antidepressants as assayed by liquid chromatography and enzyme immunoassay.
Analgesic activity of tricyclic antidepressants.
Nonlinear kinetics of trimipramine in depressed patients.
Percutaneous absorption of tricyclic antidepressants: amitriptyline, nortriptyline, imipramine, and desipramine.
Propylene glycol as a vehicle for percutaneous absorption of therapeutic agents.
Evaluation of tricyclic antidepressant plasma levels by an automated enzyme immunoassay (EMIT) in comparison to a high-performance liquid chromatographic method.
Sources of prediction error when using a Bayesian method to evaluate nortriptyline serum concentrations.
Some effects of chronic antidepressant treatments on rat brain monoaminergic systems.
Spectrophotometric determination of some antidepressant drugs using 3-methylbenzothiazolin-2-one hydrazone.
The effect of tricyclic antidepressant drugs on the isolated perfused guinea-pig heart.
High levels of tricyclic antidepressants in conventional therapy: determinant factors.
Interactions of tricyclic antidepressants and barbiturates in barbiturate-tolerant and nontolerant rats.
Sleep deprivation accelerates the response to nortriptyline.
Serial monitoring and achievement of steady state nortriptyline plasma levels in depressed children and adolescents: preliminary data.
Differentiation of the open and closed states of the ionic channels of nicotinic acetylcholine receptors by tricyclic antidepressants.
Reliability of commercially available tricyclic antidepressant levels.
Effects of mianserin, a new antidepressant, on the in vitro and in vivo uptake of monoamines.
Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers.
Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus.
Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters.
Metabolic interaction between amitriptyline and perphenazine in psychiatric patients.
Blockade of amine depletion by nisoxetine in comparison to other uptake inhibitors.
Electrocardiographic and cardiovascular changes in cats and dogs caused by high doses of amitriptyline given as conventional tablets or a sustained release preparation.
Nortriptyline and weight change in depressed patients over 60.
Interaction of chlorpromazine and nortriptyline in patients with schizophrenia.
An improved gas-liquid chromatographic procedure for the determination of amitriptyline and nortriptyline levels in plasma using nitrogen-sensitive detectors.
A sensitive gas chromatographic assay for amitriptyline and nortriptyline in plasma.
High-performance liquid chromatographic determination of amitriptyline and its main metabolites using a silica column with reversed-phase eluent. Application in mice.
Nortriptyline formation after single oral and intramuscular doses of amitriptyline.
Metabolite intermediate complexation of microsomal cytochrome P450 2C11 in male rat liver by nortriptyline.
Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption.
Tricyclic antidepressant agents. I. Comparison of the inhibition of the uptake of 3-H-noradrenaline and 14-C-5-hydroxytryptamine in slices and crude synaptosome preparations of the midbrain-hypothalamus region of the rat brain.
The noradrenaline receptor coupled adenylate cyclase system in brain. Lack of modification by changes in the availability of serotonin.
High-performance thin-layer chromatographic determination of psychopharmacologic agents in blood serum.
Nortriptyline and debrisoquine hydroxylations in Ghanaian and Swedish subjects.
A radioimmunoassay for the determination of combined amitriptyline and nortriptyline concentrations in microliter samples of plasma.
Effects of alpha-adrenoceptor agonists and antagonists and of antidepressant drugs on pre- and postsynaptic alpha-adrenoceptors.
Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes.
Gas chromatographic determination of amitriptyline, nortriptyline and perphenazine in plasma of schizophrenic patients after administration of the combination of amitriptyline with perphenazine.
Quantitative GLC determination of cis- and trans-isomers of doxepin and desmethyldoxepin.
Liquid-chromatographic determination of amitryptyline and its metabolites in serum, with adsorption onto glass minimized.
Microsomal binding of amitriptyline: effect on estimation of enzyme kinetic parameters in vitro.
Differential-reinforcement-of-low-rate 72-second schedule: selective effects of antidepressant drugs.
Avoidance enhancement and discriminative response control by anxiolytics with drugs acting on the GABA system.
Prediction of maintenance dose required to attain a desired drug concentration at steady-state from a single determination of concentration after an initial dose.
Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites.
Automated determination of drugs in serum by column-switching high-performance liquid chromatography. IV. Separation of tricyclic and tetracyclic antidepressants and their metabolites.
Tricyclic antidepressive drugs and dopamine-sensitive adenylate cyclase from rat brain striatum.
Interaction of tricyclic drug analogs with synaptic plasma membranes: structure-mechanism relationships in inhibition of neuronal Na+/K(+)-ATPase activity.
Effects of psychotropic drugs on human sperm motility.
Cardiovascular effects of amitriptyline, nortriptyline, protriptyline, and doxepin in conscious rabbits after subacute pretreatment with protriptyline.
The pupil response to E-10-hydroxynortriptyline in rabbits with ocular sympathetic paresis.
Antidepressant-induced regulation of 5-HT(1b) mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation.
Clinical and biochemical effects during treatment of depression with nortriptyline: the role of 10-hydroxynortriptyline.
Acute extrapyramidal side effects: serum levels of neuroleptics and anticholinergics.
Nortriptyline therapy in elderly patients: dosage prediction from plasma concentration at 24 hours after a single 50 mg dose.
Hydroxydesipramine in the elderly.
Quantitative homogeneous enzyme immunoassays for amitriptyline, nortriptyline, imipramine, and desipramine.
Therapeutic effect and side effects in patients with endogenous depression treated with oral nortriptyline once a day.
Clinical pharmacological evaluation of an assay kit for intoxications with tricyclic antidepressants.
On-line solid-phase extraction and high-performance liquid chromatographic determination of nortriptyline and amitriptyline in serum.
Protective effect of flavonoids on drug-induced hepatotoxicity in vitro.
Specific radioimmunoassay for amitriptyline and nortriptyline in plasma.
Effects of nortriptyline and paroxetine on QT variability in patients with panic disorder.
On the relationship between free plasma and saliva amitriptyline and nortriptyline.
Effects of mianserin on functions of ascending and descending monoaminergic systems, using experimental models
Combined thin-layer and gas-liquid chromatographic identification of tricyclic antidepressants in urine.
Cost considerations in headache treatment. Part 1: Prophylactic migraine treatment.
Nortriptyline kinetics in Hispanic and Anglo subjects.
Dual ultraviolet wavelength high-performance liquid chromatographic method for the forensic or clinical analysis of seventeen antidepressants and some selected metabolites.
Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes.
Noradrenaline, depressive illness, and the action of amitriptyline.
Double-antibody enzyme immunoassay for nortriptyline.
Plasma levels and clinical improvement--a comparative study of clomipramine and amitriptyline in depression.
Affinity screening by packed capillary high-performance liquid chromatography using molecular imprinted sorbents. I. Demonstration of feasibility.
Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic acetylcholine receptors.
Fluoxetine-induced inhibition of synaptosomal 3H5-HT release: possible Ca(2+)-channel inhibition.
Intraindividual similarity in the metabolism of amitriptyline and chlorimipramine in depressed patients.
Excretion of nortriptyline into saliva.
Comparison of the kinetic interactions of the neuroleptics perphenazine and zuclopenthixol with tricyclic antidepressives.
The effect of nortriptyline in elderly patients with cardiac conduction disease.
3H-imipramine binding sites in brain down-regulated by chronic nortriptyline and haloperidol but not mianserin treatment.
Lidocaine and amitriptyline interaction during experimental haemoperfusion.
Clomipramine and clonazepam increase cholecystokinin levels in rat ventral tegmental area and limbic regions.
Drug analysis in fly larvae.
The measurement of plasma levels of tricyclic antidepressant drugs.
Determination of nortriptyline in human serum by fully automated solid-phase extraction and on-line high-performance liquid chromatography in the presence of antipsychotic drugs.
Quantitative liquid-chromatographic technique for the simultaneous assay of tricyclic antidepressant drugs in plasma or serum.
A prospective study of lithium augmentation in antidepressant-resistant geriatric depression.
Regulation of high- and low-affinity 3Himipramine recognition sites in rat brain by chronic treatment with antidepressants.
Quantitative assay of maprotiline in biological fluids by gas-liquid chromatography.
Alpha-adrenergic receptors mediate imipramine/alarm substance-induced reaction in rats.
Mean time and first-pass metabolism.
Distribution of amitriptyline and nortriptyline in blood: role of alpha-1-glycoprotein.
A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation.
Simplified method for monitoring tricyclic antidepressant therapy using gas--liquid chromatography with nitrogen detection.
Amitriptyline and its basic metabolites determined in plasma by gas chromatography.
Determination of residues in the norepinephrine transporter that are critical for tricyclic antidepressant affinity.
A radioreceptor assay for neuroleptic drugs in plasma.
Drug induced biogenesis of nitrosamines.
Minor and clinically non-significant interaction between toloxatone and amitriptyline.
Antidepressant drugs normalize the increased social behaviour of pairs of male rats induced by short term isolation.
Determination of amitriptyline and its major basic metabolites in human urine by high-performance liquid chromatography.
First-pass metabolism of nortriptyline in man.
Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio.
No circadian effect on nortriptyline kinetics in man.
Effects of smoking on nortriptyline plasma concentrations in depressed patients.
Child and adolescent nortriptyline single dose pharmacokinetic parameters: final report.
Differential effects of tricyclic antidepressant drugs on membrane dynamics--a fluorescence spectroscopic study.
Determination of amitriptyline and nortriptyline in human plasma by quantitative thin-layer chromatography.
Displacement of nortriptyline and uptake of 14C-lidocaine in the lung after administration of 14C-lidocaine to nortriptyline intoxicated pigs.
Determination of amitriptyline-N-oxide, amitriptyline and nortriptyline in serum and plasma by high-performance liquid chromatography.
Novel 125I-labeled nortriptyline derivatives and their use in liquid-phase or magnetizable solid-phase second-antibody radioimmunoassays.
Amitriptyline and amitriptyline metabolites in blood and cerebrospinal fluid following human overdose.
Factors influencing nortriptyline steady-state kinetics: plasma and saliva levels.
The production of amitriptyline from nortriptyline in formaldehyde-containing solutions.
First pass hydroxylation of nortriptyline: concentrations of parent drug and major metabolites in plasma.
Studies on accumulation of (14C)-mescaline in brain homogenates: effects of psychotropic and other agents.
Pharmacological comparison of the rat and guinea-pig cortical high affinity 5-hydroxytryptamine uptake system.
Use of charge-transfer complex formation for the spectrophotometric determination of nortriptyline.
Cerebrospinal fluid levels of amitriptyline, nortriptyline, imipramine and desmethylimipramine. Relationship to plasma levels and treatment outcome.
Weight gain. A side-effect of tricyclic antidepressants.
MAO inhibition and control of anxiety following amitriptyline therapy. A pilot study.
Simultaneous HPLC analysis of tricyclic antidepressants and metabolites in plasma samples.
Comparative animal studies on cardiovascular toxicity of tri- and tetracyclic antidepressants and citalopram; relation to drug plasma levels.
Potentiation of the action of reserpine on the frog as a characteristic effect of antidepressants
Stereoselective disposition of racemic E-10-hydroxynortriptyline in human beings.
Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged.
Radioimmunoassay of amitriptyline and nortriptyline in body fluids.
Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics.
Tricyclic antidepressants and cardiac conduction: changes in ventricular automaticity.
Pharmacokinetics of amitriptyline infused intravenously in man.
Phenolic metabolites of amitriptyline and nortriptyline in rat bile.
Single oral dose pharmacokinetics of amitriptylinoxide and amitriptyline in humans.
Amitriptyline pharmacokinetics and clinical response: I. Free and total plasma amitriptyline and nortriptyline.
In vitro reaction of formaldehyde with fenfluramine: conversion to N-methyl fenfluramine.
Changes in platelet 3H-imipramine binding with chronic imipramine treatment are not state-dependent.
Determination of amlodipine in human plasma by high-performance liquid chromatography with fluorescence detection.
Determination of fluoxetine and its metabolite norfluoxetine in human liver microsomes by reversed-phase HPLC in vitro.
Effect of amitriptyline and nortriptyline on the intracular pressure and aqueous humor dynamics in rabbits
Contribution to the pharmacokinetics of amitriptyline.
Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort ( Hypericum perforatum ).
Platelet membrane fluidity and treatment response in cognitively-impaired, depressed elderly: initial results.
Course and rate of antidepressant response in the very old.
Differential modulation of efficiency in a food-rewarded "differential reinforcement of low-rate" 72-s schedule in rats by norepinephrine and serotonin reuptake inhibitors.
Plasma levels of tricyclic antidepressants and clinical efficacy: review of the literature -- part II.
Kinetics of nortriptyline in man according to a two compartment model.
Risk factors for falls during treatment of late-life depression.
Polymer-coated fibrous extraction medium for sample preparation coupled to microcolumn liquid-phase separations.
Tricyclic antidepressants as long-acting local anesthetics.
Determination of tricyclic antidepressants by high-performance liquid chromatography.
Mice plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after half-life repeated administration. Comparison with acute administration.
Analysis of eighteen antidepressants, four atypical antipsychotics and active metabolites in serum by liquid chromatography: a simple tool for therapeutic drug monitoring.
Antinociceptive effects of tricyclic antidepressants and their noradrenergic metabolites.
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Brain 5-HT1C receptors and antidepressants.
Therapeutic drug monitoring of 13 antidepressant and five neuroleptic drugs in serum with liquid chromatography-electrospray ionization mass spectrometry.
Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity.
A novel system for the determination of antidepressant concentrations in human breast milk.
Effects of a secondary and a tertiary amine tricyclic antidepressant on cerebral biogenic amines as a function of mouse strain: a comparative neurotoxicological evaluation.
Adjunctive lithium carbonate in nortriptyline-resistant elderly depressed patients.
Effects of prazosin and phentolamine on responses to field stimulation and to noradrenaline in vas deferens and anococcygeus muscle of the rat.
Substitution of psychoactive drugs in pentobarbital-dependent rats.
Effects of amitriptyline and nortriptyline on cerebral activity of the CDF-1 mouse strain.
Evaluation of the Abbott ADx total serum tricyclic immunoassay.
Serotonin and antidepressant drugs antagonize melatonin-induced behavioural changes after injection into the nucleus accumbens of rats.
Glucuronides of hydroxylated metabolites of amitriptyline and nortriptyline isolated from rat bile.
Plasma levels and effects of nortriptyline in geriatric depressed patients.
Open-trial response to antidepressant treatment in elderly patients with mixed depression and cognitive impairment.
Relationship between surface activity and toxicity to Chang liver cultures of tricyclic antidepressants.
Anomalous results of studies on drug interaction in man. I. Nortriptyline and antipyrine.
Cardiovascular and autonomic actions of ciclazindol and tricyclic antidepressants.
Determination of drugs in plasma by high-performance thin-layer chromatography.
E- and Z-10-hydroxylation of nortriptyline by human liver microsomes--methods and characterization.
Membrane action of tricyclic drugs. Spectroscopic studies of a series of phenothiazines compared with tricyclic antidepressive substances in red cell membrane, using the spin labelling technique.
The study of tricyclic antidepressants in formalin-fixed human liver and formalin solutions.
Binding of amitriptyline and nortriptyline in plasma determined from their equilibrium distributions between red cells and plasma, and between red cells and buffer solution.
Cardiac effects of tricyclic antidepressant medication. A preliminary study of nortriptyline.
Significance of lipoproteins in serum binding variations of amitriptyline, nortriptyline, and quinidine.
Tricyclic antidepressants: a simplified approach for the routine clinical monitoring of parent drug and metabolites in plasma using HPLC.
ECG changes during treatment with nortriptyline in a once-a-day dosage.
Hemoperfusion with Amberlite resin in the treatment of self-poisoning.
Therapeutic drug monitoring with the help of serum concentration measurements. How are the analytic results distributed in a population?
Valpromide increases the plasma concentrations of amitriptyline and its metabolite nortriptyline in depressive patients.
Tricyclic antidepressants inhibit human natural killer cells.
Biotransformation of amitriptyline by Cunninghamella elegans.
Dosing of antidepressants--the unknown art.
Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: application to amitriptyline N-demethylation.
Predictive value of tryptophan/large neutral amino acids ratio to antidepressant response.
Pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites in streptozocin-induced diabetic rats.
Binding and competitive inhibition of amine uptake at postsynaptic neurones (transport-P) by tricyclic antidepressants.
Antidepressant and anxiolytic profiles of E-10-hydroxynortriptyline on electrocorticograms of rats.
Quantitative analysis of amitriptyline and nortriptyline in human plasma and liver microsomal preparations by high-performance liquid chromatography.
Evaluation of a colloidal metal immunoassay device for the detection of tricyclic antidepressants in urine.
Cardiovascular changes and plasma drug levels after amitriptyline overdose.
Effect of tricyclic antidepressants on switching to mania and on the onset of bipolarity in depressed 6- to 12-year-olds.
Stereoselective and simultaneous measurement of cis- and trans-isomers of doxepin and N-desmethyldoxepin in plasma or urine by high-performance liquid chromatography.
Implication of beta 1- and beta 2-adrenergic receptors in the antinociceptive effect of tricyclic antidepressants.
Investigation of pharmacokinetics and of possible adverse effects in infants exposed to tricyclic antidepressants in breast-milk.
Nortriptyline and its hydroxymetabolites in breastfeeding mothers and newborns.
Effects of tricyclic and tetracyclic antidepressants on the three subtypes of GABA transporter.
Metabolism of carteolol by cDNA-expressed human cytochrome P450.
Clinical evaluation of Toxi.Prep: a semiautomated solid-phase extraction system for screening of drugs in urine.
Amitriptyline accumulation and elimination in Calliphora vicina larvae.
Aggregation of antidepressant drugs in aqueous solution.
Brain morphology and response to nortriptyline in geriatric depression.
Elevated levels of erythropoietin in cerebrospinal fluid of depressed patients.
Economic outcomes with antidepressant pharmacotherapy: a retrospective intent-to-treat analysis.
Cardiovascular effects of fluoxetine in depressed patients with heart disease.
Effects of age at onset of first lifetime episode of recurrent major depression on treatment response and illness course in elderly patients.
Measurement of plasma levels of tricylic psychoactive drugs and their metabolites by UV reflectance photometry of thin layer chromatograms.
Experimental tricyclic antidepressant toxicity: a randomized, controlled comparison of hypertonic saline solution, sodium bicarbonate, and hyperventilation.
High-performance liquid chromatography-mass spectrometry for the quantification of nortriptyline and 10-hydroxynortriptyline in plasma.
Monitoring of tricyclic antidepressants in human serum and plasma by HPLC: characterization of a simple, laboratory developed method via external quality assessment.
An animal model of postmortem amitriptyline redistribution.
Evaluation of amitriptyline pharmacokinetics during peritoneal dialysis.
Determination of amitriptyline and nortriptyline in human liver microsomes with reversed-phase HPLC in vitro.
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