Drugs online research references
Int J Clin Pharmacol Ther Toxicol. 1988 Jul;26(7):351-5.
Treatment of hypertensive emergencies with nifedipine.
Karachalios GN, Donas G, Tsimiklis S, Stathakakis V.
Department of Medicine, Kalamata General Hospital, Greece.
The effects and safety of using sublingually nifedipine 10-20 mg as acute antihypertensive treatment were evaluated in 108 patients with hypertensive emergencies or urgency without intensive care monitoring. Before treatment, mean systolic blood pressure was 220 +/- 28 mmHg, mean diastolic blood pressure was 125 +/- 15 mmHg and mean arterial pressure was 155 +/- 14 mmHg. Administration of 10 mg of sublingual nifedipine reduced the blood pressure within 10 min and produced a peak effect level between 30 to 40 min. Blood pressure decreased significantly to a mean 155 +/- 20 and 92 +/- 14 mmHg systolic and diastolic blood pressure, respectively. Minimal adverse effects was observed. Five patients, required additional therapy with other antihypertensive drugs. Heart rate increased from 74 +/- 10 to 84 +/- 10 beats per min. The response to nifedipine correlated with the blood pressure value prior to treatment, but did not correlate with age or the type of hypertensive emergency. These results indicate that nifedipine administered sublingually is a simple, effective, and safe agent for treating hypertensive emergencies, especially for the patients in whom intensive care monitoring cannot be guaranteed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3209283&dopt=Abstract
Am J Med. 1985 Oct 11;79(4A):31-5.
Treatment of hypertensive emergencies with the calcium channel blocker nifedipine.
Bertel O, Conen LD.
The severe elevations in blood pressure that occur in hypertensive emergencies pose a serious threat to life or vital organ functions. However, use of antihypertensive agents to acutely reduce blood pressure during hypertensive emergencies may cause deficits in the perfusion of the central nervous system or the heart. Therefore, a knowledge of cerebral blood flow regulation during acute treatment of hypertensive emergencies is indispensable. Experience with the calcium channel blocker nifedipine in the acute treatment of patients with hypertensive emergencies has shown that this agent has a pronounced vasodilatory effect, especially in vessels with a high vasoconstrictor tone, and that it does not reduce cardiac output or cerebral blood flow. The drug is highly efficacious and safe, and reports of serious side effects are rare. However, nifedipine should be used with caution in patients with suspected or proved critical arteriosclerotic stenosis of the cerebral arteries, because a reduction in perfusion pressure with any drug places these patients at risk for development of ischemic symptoms. Nifedipine can be used as a first-line drug for acute reduction of blood pressure in patients with hypertensive emergencies.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4050843&dopt=Abstract
Am Fam Physician. 1985 Jul;32(1):97-109.
Hypertensive emergencies.
Burris JF.
Hypertensive emergencies require prompt and aggressive treatment to prevent target organ damage and death. A variety of neurologic, cardiac, renal and other conditions may underlie a hypertensive crisis. A number of highly effective drugs are now available to treat hypertensive crises, including well-known agents like sodium nitroprusside and diazoxide, as well as newer drugs such as nifedipine and captopril. Some older medications have been superseded by newer agents.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4013967&dopt=Abstract
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