Drugs online research references
Br Heart J. 1981 Sep;46(3):320-4.
Prognostic significance of electrocardiographic findings in angina at rest. Therapeutic implications.
Demoulin JC, Bertholet M, Chevigne M, Legrand V, Renier J, Soumagne D, Soyeur D, Limet R, Kulbertus H.
Ninety-five patients with angina at rest were observed in the coronary care unit. Eighty-one per cent presented concomitantly or had previously presented some other manifestations of coronary artery disease. These patients were divided into two subgroups. In subgroup 1 (40 patients), episodes of non-exertional angina were associated with a pattern of hyperacute subepicardial injury and, frequently, with ventricular arrhythmias. In subgroup 2 (55 patients), the episodes of angina at rest were attended by horizontal ST depression, isolated T wave inversion, or trivial ST-T changes. Coronary angiographic findings were similar in both subgroups. Symptoms regressed in only 9% of patients in subgroup 1 while they were receiving beta-receptor antagonists, whereas amiodarone alone or amiodarone with nifedipine was successful in 58%. Of these patients, 25% developed a myocardial infarction shortly after admission. In subgroup 2 patients, beta-blockers were successful in 61%. Amiodarone isolated or associated with nifedipine was successful in 55% of the patients in whom it was tried. Only 5% of patients in this subgroup developed a myocardial infarction during their hospital stay. It is concluded that: (1) observation of the electrocardiogram during spontaneous angina in patients with known atherosclerotic coronary heart disease may be of prognostic significance and may influence therapeutic decision. (2) Amiodarone by virtue of its anginal and antiarrhythmic properties may be particularly useful in the treatment of non-exertional angina.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6117297&dopt=Abstract
G Ital Cardiol. 1980;10(10):1334-9.
[Angina at rest. Clinical, electrocardiographic and angiographic observations in 107 patients]
[Article in Italian]
Casali PM, De Servi S, Ardissino D, Martinelli L, Mussini A, Bramucci E, Falcone C, Minzioni G, Vigano M, Specchia G, Bobba P.
107 patients suffering from angina at rest associated with ST segment changes underwent coronary arteriography. 46 patients showed ST segment elevation during ischemic attacks (group I) while 61 patients exhibited ST segment depression during chest pain (group II). Non-significant coronary artery disease was more frequent in group I patients (group I 15%, group II 5%) as well as one vessel disease (group I 33%, group II 15%) while multivessel disease and left main involvement were more frequent in group II patients (group I 28%, group II 60%). Depression of left ventricular function was found in similar percentage of cases in both groups. During hospitalization all patients were treated with calcium antagonists (Nifedipine 10/20 mg every six hours) and/or nitrates (2% nitroglycerin ointment 2 inches every six/four hours) with one death (occurring after coronary arteriography) and eleven non-fatal myocardial infarctions. 50 patients underwent coronary bypass grafting with four perioperative deaths and six nonfatal myocardial infarctions. Most of the surgically treated patients were poorly responsive to medical treatment and had multivessel disease or left main involvement. Since these features are known to be related to a poor prognosis with medical treatment, surgical results in such patients seem satisfactory.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6786946&dopt=Abstract
Methods Find Exp Clin Pharmacol. 1981 Jan-Feb;3(1):17-27.
Evaluation of the clinical electrophysiological effects of antianginal drugs without specific antiarrhythmic properties.
Franchi F, Padeletti L.
The authors have studied the electrophysiological effects of four antianginal drugs: oxyfedrine, nifedipine, dipyridamole and carbochromene. These drugs demonstrated different and sometimes contrasting effects on sinus node function, atrial refractoriness and atrioventricular conduction. These effects may constitute an indication or a contraindication in different clinical pictures and should be considered in the choice of treatment of patients with coronary artery disease.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7230972&dopt=Abstract
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