Drugs online research references
Pharmacol Res Commun. 1986 Dec;18(12):1107-17.
Membrane activity, antioxidant, antiaggregatory and antihemolytic properties of four calcium channel blockers.
Robak J, Duniec Z.
Four calcium channel blockers: nifedipine, fendiline, verapamil and diltiazem have been found to possess different affinity to cytomembranes of platelets and erythrocytes. Nifedipine bound to proteins of the external site of cytomembranes. Verapamil and fendiline possessed affinity to lipids of the cytoplasmic site of the cytomembranes. Diltiazem bound practically neither to erythrocyte nor to platelet membranes. All tested compounds were antioxidants, the strongest being fendiline. Antiaggregatory and antihemolytic properties of tested compounds were roughly correlated with their membrane activity.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3562505&dopt=Abstract
Mol Pharmacol. 1991 Sep;40(3):435-9.
Spin-trapping and antioxidant properties of illuminated and nonilluminated nifedipine and nimodipine in heart homogenate and model system.
Misik V, Stasko A, Gergel D, Ondrias K.
Institute of Experimental Pharmacology, Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Nifedipine [1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic+ ++ acid dimethyl ester] and nimodipine [1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic+ ++ acid 2-methoxyethyl 1-methylethyl ester], incorporated into diheptanoylphosphatidylcholine liposomes, which were used as a drug carrier system, slightly inhibited lipid peroxidation (induced by tert-butylhydroperoxide and Fe2+) in rat heart homogenate. Illumination of nimodipine had no effect on its antioxidant potency, whereas illuminated nifedipine was several times more effective than nonilluminated drug. On illumination, nifedipine converts to 2,6-dimethyl-4-(2-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (NTP). NTP formed stable radicals when interacting with the rat heart homogenate and dioleoylphosphatidylcholine, as detected by EPR spectroscopy. No radical formation was observed if nonilluminated nifedipine and nimodipine or illuminated nimodipine were used. The spin density of the unpaired electron in the NTP-adduct was centered on the nitrogen derived from its nitroso group. The motion of the NTP-adduct radical was restricted, indicating that the radicals were located in the membrane of the homogenate and not in the buffer system. Only NTP (not nifedipine or nimodipine) was effective in trapping free radicals formed by the thermal or photoinduced decomposition of 2,2'-azobisisobutyronitrile and radicals formed by photolysis of di-tert-butylperoxide. The antioxidant and spin-trapping properties of NTP in our systems were attributed to its nitroso group.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1654516&dopt=Abstract
Jpn J Pharmacol. 1998 Dec;78(4):435-41.
Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats.
Suzuki Y, Ishihara M, Segami T, Ito M.
Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
When free radical-scavenging activities of quercetin, alpha-tocopherol, nifedipine and tetracycline were measured by an electron spin resonance technique, all test compounds (10(-5) to 10(-3) M) scavenged both superoxide anions and hydroxyl radicals. The oral administration of quercetin (50 and 100 mg/kg), alpha-tocopherol (8 and 16 mg/kg), nifedipine (20 and 40 mg/kg) or tetracycline (10 and 20 mg/kg) markedly prevented the HCl plus ethanol-induced gastric mucosal injury and the increase in the content of thiobarbituric acid-reactive substances in the injured mucosa in rats. In addition, quercetin (25, 50 and 100 mg/kg), alpha-tocopherol (4, 8 and 16 mg/kg), nifedipine (10, 20 and 40 mg/kg) and tetracycline (5, 10 and 20 mg/kg), given orally, twice daily for 14 consecutive days from the day after acetic acid injection, dose-dependently promoted the ulcer healing and inhibited the increase in the content of thiobarbituric acid-reactive substances in the ulcerated mucosa. These results indicate that quercetin, alpha-tocopherol, nifedipine and tetracycline possess gastric cytoprotective and gastric ulcer healing-promoting actions. In addition, the free radical-scavenging properties of these compounds may be partly related to their anti-ulcer effects.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9920200&dopt=Abstract
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