Drugs online research references
Anticancer Res. 2001 Jan-Feb;21(1A):269-73.
Enhanced antibacterial effect of erythromycin in the presence of 3,5-dibenzoyl-1,4-dihydropyridines.
Gunics G, Motohashi N, Molnar J, Farkas S, Kawase M, Saito S, Shah A.
Faculty of Medicine, Institute of Microbiology, Albert Szent-Gyorgyi Medical University, Szeged, Hungary.
Fifteen 3,5-dibenzoyl-1,4-dihydropyridines (BzDHP, GB1-GB15) (nifedipine (NP) analogs) were tested on three different E. coli strains. The compounds had relatively high MIC values on these strains. In combination with erythromycin (Er), compounds (G1,3,4,6,7,10,12) reduced MIC values of Er. When the BzDHPs were tested on E. coli Gy-1/Apsen.Erres strain isolated from a clinical specimen, the reduction of MIC values were similar to the previous strains, but not identical. In the polyresistant clinically isolated E. coli Gy-2/Apres.Erres strain, the MIC values of Er were slightly reduced in the presence of GB1-GB7. Compound GB12 was the most effective in enhancing the activity of Er, and was selected for plasmid elimination studies. However, GB12 itself had no antiplasmid effect and did not alter the promethazine induced plasmid elimination.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11299745&dopt=Abstract
Pharmacology. 1992;45(5):250-9.
Comparative inhibitory effects of dihydropyridines on platelet aggregation, calcium uptake and cyclic AMP concentration.
Blache D, Ojeda C.
INSERM U. 63, Bron, France.
We studied the in vitro effects of several calcium channel blockers from the dihydropyridine (DHP) family on platelet aggregation and endogenous serotonin secretion, calcium uptake and cyclic AMP (cAMP) concentration using washed rat platelets. We found that, after 1 min incubation, nifedipine (Nif), nitrendipine (Nit) and nisoldipine (Nis) inhibited the thrombin-induced platelet aggregation and serotonin secretion with IC50 of about 140, 5 and 2 mumol/l, respectively. Nis and Nit are thus much more active than Nif. We also found that the thrombin-induced Ca2+ uptake amounted to 2,600 +/- 326 pmol Ca2+/10(9) platelets in control conditions. In the presence of 10 mumol/l of the DHP, this uptake was decreased by 19, 49 or 77%, with Nif, Nit or Nis, respectively. Compound BAY K 8644 (BK) with known agonistic properties on the calcium channel had inhibitory effects on the studied parameters. These compounds were in the order of Nif < BK < Nit < Nis. When added to previously aggregated platelets, Nit caused them to deaggregate. These results seem to be similar to those obtained with cAMP analogues or adenylate cyclase activators. The platelet resting cAMP concentration was therefore measured in the presence of the DHP. A nonsignificant increase was found with 20 mumol/l Nif whereas significant increases of 20 and 68% as compared with controls were obtained with 20 mumol/l Nit and Nis, respectively. Partition studies between platelets and plasma lipoproteins indicated that the effects might be related to the lipophilicity of the compounds. These data suggest that these agents work on platelet activity by multiple effects located intracellularly or at the membrane level.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1334562&dopt=Abstract
Psychopharmacology (Berl). 1990;100(1):124-9.
Behavioral performance effects of nifedipine in normotensive and renovascular hypertensive baboons.
Turkkan JS, Hienz RD.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Behavioral performances of normotensive and hypertensive adult male baboons were tested before, during, and following chronic oral dosing with nifedipine. Performances during a five-color simultaneous match-to-sample task were measured during three dosing schedules (0.20, 0.68, and 1.14 mg/kg/day) and vehicle. Each dose was administered for 21 consecutive days preceded and followed by 14-day baseline and recovery periods, respectively. Choice reaction times increased by 191 ms over baseline at the 0.68 mg/kg dose. Choice reaction times above the 95th percentile (i.e., the slowest reaction times) were the most slowed by nifedipine. Accuracy of color matching was decreased at 0.20 and 0.68 mg/kg by an average range of 2-4%. The yellow and white stimuli were the most difficult to discriminate correctly, and were also the most impaired by nifedipine. Nifedipine's behavioral effects were not modulated by blood pressure changes because daily changes in choice reaction time and systolic blood pressure were not correlated, and hypertensive status did not determine the behavioral effects. Potential sources of nifedipine's behavioral performance effects are discussed, with blood pressure changes excluded as a probable mechanism.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2296620&dopt=Abstract
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Wellstreet online pharmacy for click-order prescription medications ||
Altace Online Pharmacy ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Insurance plans and information ||
Insurance policies for all purposes ||
Antibiotics and prescription medications online literature ||