Drugs online research references
Klin Med (Mosk). 1990 Jul;68(7):56-60.
[Evaluation of the effectiveness of calcium antagonists combined with digoxin and furosemide in hypertension complicated by circulatory insufficiency in elderly patients]
[Article in Russian]
Orynchak MA.
Clinical, hemodynamic and neurohumoral data are available supporting the validity of a differentiated approach to administration of combined treatment with furosemide, digoxin and calcium antagonists nifedipine and verapamil in advanced-aged patients with hypertension complicated by circulatory disorders. The choice of the drugs should be based on the criterion of per hour diuresis following a single dose of the combination.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2232650&dopt=Abstract
Vnitr Lek. 1996 Feb;42(2):102-5.
[Evaluation of the effectiveness of antihypertensive therapy. Is the trough-peak ratio the determining factor?]
[Article in Czech]
Widimsky J.
Klinika kardiologie IPVZ, Praha.
The author describes the assessment of the effectiveness of antihypertensive drugs according to the T-P (Trough-Peak) ratio, i.e. the effect at the end of the dosage period to the effect during its peak after subtraction of the placebo effect. He draws attention to methodological difficulties which make it so far difficult to compare data from the literature. It is, however, advisable in clinical practice of the treatment of hypertension to assess the blood pressure at the end of the dosage period rather than during the peak of effectiveness, as frequently practiced. Drugs with a long biological half-life are particularly useful. The most important criterion of effectiveness of antihypertensives is, however, their effect on the cardiovascular and cerebrovascular mortality and morbidity. Only on diuretics and beta-blockers extensive data are available indicating that they lead to a decline of the morbidity and mortality. Therefore they should be the drugs of first choice, in particular in elderly hypertonics. Data on calcium channel blockers, in particular nifedipine are controversial. ACE inhibitors are suitable in heart failure, asymptomatic dysfunction after acute myocardial infarction and in type 1 diabetes mellitus. Only at present investigations are under way to assess whether the effect of new and more expensive antihypertensives on mortality and morbidity is greater than the effect of diuretics and beta-blockers and whether they will be suitable drugs of first choice.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8686181&dopt=Abstract
C R Seances Soc Biol Fil. 1979;173(4):773-80.
[Prolongation of the effective refractory period on isolated guinea pig atria by some anti-arrhythmia agents: relevance in a comparison of their potentialities]
[Article in French]
Leinot M, Basiez M, Talvard J, Labrid C.
The effects of bepridil, nifedipine, verapamil, lignocaine and amiodarone on the atrial effective refractory period were investigated in the guinea-pig. The observed results permitted elucidation of a remarkable activity by both nifedipine and verapamil, and by bepridil and lignocaine. In contrast, in the experimental conditions, no activity was detected with amiodarone up to concentrations of 10(-4) M. The efficacity rating of the test compounds is not reflected by their anti-arrhythmic efficacity as demonstrated in vivo in the animal, nor by their therapeutic anti-arrhythmic efficacity as reported in the clinical literature. However, this efficacity rating may be related to the interaction of the compounds with the transmembrane sodium or calcium movements.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=160823&dopt=Abstract
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