Drugs online research references
J Chromatogr B Biomed Sci Appl. 2001 Jun 5;757(1):127-33.
High-performance liquid chromatographic assay for the simultaneous determination of lansoprazole enantiomers and metabolites in human liver microsomes.
Katsuki H, Hamada A, Nakamura C, Arimori K, Nakano M.
Department of Pharmacy, Kumamoto University Hospital, Japan.
In this study, a simple, sensitive and enantioselective HPLC method was developed for the simultaneous determination of lansoprazole enantiomers: a proton pump inhibitor, and its major metabolites: 5-hydroxylansoprazole and lansoprazole sulfone in human liver microsomes. After extraction from the microsomal incubation mixture with a diethyl etherdichloromethane (7:3, v/v) mixture, analytes were measured by reversed-phase HPLC on a Chiralcel OD-R column. Detection was made using an ultraviolet absorbance detector set at a wavelength of 285 nm. The mobile phase consisted of a methanol-water (75:25, v/v) mixture. At a flow-rate of 0.5 ml/min, the total run time was 35 min. The limit of quantification for both lansoprazole enantiomers was 0.25 microM and for the metabolites 0.13 microM. The method is suitable for the analysis of lansoprazole enantiomers and its metabolites from human microsomal liver incubations.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11419737&dopt=Abstract
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Lik Sprava. 2002 Jul-Sep;(5-6):24-6.
[Microcirculation in gastric mucosa as related to its secretory activity in patients with peptic ulcer]
[Article in Ukrainian]
Shcherbynina MB.
A study was made into the condition of the capillary bed in 18 patients with peptic ulcer before and under exposure to lansoprazole treatments. Biopsy specimens were taken from the lesser curvature of the stomach: in the area of the upper third (intact zone) and lower third from the ulcer periphocal zone. It is the regional redistribution of blood in the gastric mucosa rather than amount of hydrochloric acid and pepsins in the gastric contents that has the most important part in pathogenetic mechanisms of ulcer formation in the stomach.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12442513&dopt=Abstract
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Dig Dis Sci. 2002 Nov;47(11):2486-92.
Effects of omeprazole and ascorbate on gastric emptying and antioxidant levels in a mouse model of glutathione depletion.
Koch TR, Yuan LX, Petro A, Opara EC.
Section of Gastroenterology, LA Johnson VA Medical Center and West Virginia University, Morgantown, West Virginia 26506, USA.
Increased free radical production with depletion of the antioxidant, glutathione, is a suggested mechanism for the development of ulcer disease in patients with Helicobacter pylori. The effects of ascorbate and omeprazole as potential gut antioxidants are incompletely understood. We hypothesized that as antioxidants, ascorbate and omeprazole protect against glutathione depletion. This study was designed to determine the effects of ascorbate and omeprazole on gastric emptying and gastric antioxidant levels in a mouse model of glutathione depletion. In an acute (10-day) mouse model, glutathione depletion was induced by inhibiting the rate limiting enzyme, gamma-glutamylcysteine synthetase. Enzymatic blockade produced depletion of gastric glutathione (P < 0.05) without increasing gastric lipid hydroperoxides. Glutathione depletion was associated with accelerated liquid gastric emptying. These effects were not prevented by supplementation with ascorbate or omeprazole. Omeprazole induced increased (P < 0.05) gastric and colonic total antioxidant capacity. One of the beneficial effects of omeprazole in patients may involve increased total antioxidant capacity.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12452384&dopt=Abstract
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