Drugs online research references
mdanderson.org
BACKGROUND: Fibrinogen is an important risk factor for ischaemic heart disease (IHD) (1) and an elevated fibrinogen level has been reported in younger patients infected with Helicobacter pylori (H pylori) infection (2, 3). However, the effect of Helicobacter pylori infection on fibrinogen level in elderly population with IHD is not known. Also in particular the effect on fibrinogen with eradication of Helicobacter pylori has not been previously reported.The aim of this study was to investigate the influence of H pylori on fibrinogen levels in elderly patients with IHD and to assess the effect of eradication therapy on fibrinogen levels. PATIENTS AND METHODS: Forty patients over the age of 65 years presenting with symptomatic IHD and an age-matched control group of 21 patients were studied.The 14-C urea breath test was used for detecting H pylori infection. Patients found to be H pylori positive were treated with omeprazole 40 mg daily and amoxicillin 500 mg three times daily for 14 days. Fibrinogen concentration was measured at the beginning of treatment and repeated at 4 weeks after completion of treatment along with the urea breath test in those tested positive for H pylori and fibrinogen level was repeated at 6 weeks in the H pylori negative patients. RESULTS: The prevalence of H pylori infection was 19/40 (47.5%) in the IHD group and 9/21 (42.8%) in the control group.The median serum fibrinogen level was 4.34 g/l (3.73-6.04 i.q. range) in H Pylori positive patients and 4.86 g/l (3.58-6.11 i.q. range) in H Pylori negative patients in both the IHD and age-matched control group, with no significant difference between the two groups, p = 0.78 (Mann-Whitney test). In the IHD group 27/40 (67.5%) had a fibrinogen level >4.0 g/l compared to 11/21 (52.3%) in the control group.The median fibrinogen level decreased significantly from 5.75g/l (i.q. range 4.39-6.71) to 4.41 g/l (i.q. range 3.80-6.06) after eradication treatment of H pylori in patients with raised fibrinogen levels (p < 0.01). CONCLUSION: The presence of H Pylori infection did not correlate with the presence of IHD, and the fibrinogen level was not raised in the IHD group. However, in elderly patients with H pylori infection, eradication therapy lowered fibrinogen levels in those with elevated (>4.0 g/l) fibrinogen level.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12405567&dopt=Abstract
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yahoo.com
The compensation method and other chemometric methods (derivative, orthogonal function and difference spectrophotometry) have been applied to the direct determination of omeprazole, lansoprazole and pantoprazole in their pharmaceutical preparations. The methods have been validated; the limits of detection were found to be 3.3x10(-2), 3.0x10(-2) and 3.5x10(-2) microgram ml(-1) for the three drugs, respectively. The repeatabililty of the methods were found to be 0.3-0.5%. The linearity ranges were found to be 0.5-3.5 microgram ml(-1). The proposed methods have been applied to the determination of the three drugs in their grastro-resistant formulations. The difference spectrophotometric (DeltaA) method is unaffected by the presence of acid induced degradation products; hence can be used as a stability indicating assay.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12408904&dopt=Abstract
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tmig.or.jp
INTRODUCTION: Digestive organs are controlled from the central nervous system, and the vagus nerve plays an important role. Orexins are recently purified neuropeptides localized in neurons within the lateral hypothalamus. AIM: To examine the effects of centrally injected Orexin-A and B on pancreatic exocrine secretion in conscious rats. METHODOLOGY: Rats were prepared with cannulae draining bile and pancreatic juice separately. The experiments were conducted without anesthesia on day 4 or 5 after the operation. RESULTS: Intracerebroventricular administration of Orexin-A (0.25, 0.5, and 1.0 nmol) significantly increased pancreatic fluid and protein output in a dose-dependent manner. A significant stimulatory effect of Orexin-B was not observed. Pretreatment with the ganglion blocker hexamethonium and with atropine completely abolished the stimulatory effect of central Orexin-A. Central Orexin-A significantly increased pancreatic secretion after pretreatment with omeprazole. Intravenous injection of Orexin-A had no effect. Centrally administered Orexin-A stimulated the vagal efferent nerve in anesthetized rats. CONCLUSIONS: Centrally administered Orexin-A stimulates pancreatic exocrine secretion through the vagal efferent nerve, and the stimulatory action is independent of gastric acid secretion.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12409836&dopt=Abstract
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