Drugs online research references
J Hosp Infect. 1995 Apr;29(4):265-73.
Methicillin-resistant Staphylococcus aureus (MRSA) isolated in clinics and hospitals in the Fukuoka city area.
Kono K, Arakawa K.
Second Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
Bacteriological and clinical studies were carried out on 280 strains of Staphylococcus aureus isolated in clinics and hospitals in the Fukuoka city area from September 1990 to March 1991. The percentage of methicillin-resistant S. aureus (MRSA) strains studied was 41.4% (116 of 280). Of 116 MRSA strains, 48 (41.3%) produced coagulase VII and 21 (18.1%) produced coagulase II. The mean age of the patients who harboured MRSA, 70.5 +/- 16.9 years, was significantly higher than that of patients with methicillin-sensitive S. aureus (MSSA), 44.2 +/- 29.3 years (P < 0.001). MRSA was detected more frequently than MSSA in sputum (P < 0.01), while MSSA was detected more frequently than MRSA in pus (P < 0.01). Ninety (89.1%) of 101 strains of MRSA were isolated from inpatients and 98 (71.0%) of 130 strains of MSSA were isolated from outpatients. Similar number of MRSA strains were recovered in a variety of hospitals, indicating that there was no relationship between hospital size (number of beds) and the incidence of MRSA. As for drug susceptibility, coagulase VII-producing MRSA strains were more sensitive to clidamycin (P < 0.01) and more resistant to minocycline (P < 0.01) than were other MRSA strains.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7658006&dopt=Abstract
J Chemother. 1995 Apr;7(2):118-25.
Effect of antimicrobial agents on chemotaxis of polymorphonuclear leukocytes.
Sugita K, Nishimura T.
Department of Pediatrics, Osaka Medical College, Japan.
The effect of antimicrobial agents on polymorphonuclear (PMN) chemotaxis was investigated. No significant effect was obtained in vitro with penicillins, cephems, macrolides, aminoglycosides or quinolones by the agarose plate method. However, chemotaxis was inhibited at 100 micrograms/ml or less of minocycline and doxycycline. The inhibitory effect on chemotaxis is considered to be due to chelation of Ca-ions by minocycline or doxycycline. The chelation reduced the concentrations of Ca-ions in the PMNs. The chemotactic index of minocycline increased when CaCl2 or A23187 were given in combination. Our findings indicate that a small number of the short lamellipodia were observed in PMNs preincubated with minocycline or doxycycline and these two agents affected the movement of PMNs morphologically.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7666117&dopt=Abstract
In Vivo. 1995 Jan-Feb;9(1):11-8.
Increased efficacy of chemo- and radio-therapy by a hemoglobin solution in the 9L gliosarcoma.
Teicher BA, Dupuis NP, Emi Y, Ikebe M, Kakeji Y, Menon K.
Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Tissue oxygen tensions were measured in the rat 9L gliosarcoma under conditions of normal air breathing or carbogen breathing and after intravenous administration of a hemoglobin solution with air breathing or carbogen breathing. Administration of the hemoglobin decreased the level of hypoxia in the tumors. Treatment of the animals with the antiangiogenic combination of TNP-470 and minocycline also increased tumor oxygenation compared with untreated controls. Treatment with the antiangiogenic agents along with administration of the hemoglobin solution/carbogen breathing decreased the hypoxic fraction (% pO2 readings < or = 5 mmHg) from 71 % to 30%. Treatment of the tumor-bearing animals with BCNU or adriamycin modestly reduced hypoxia in the tumors, while treatment with fractionated radiation markedly increased hypoxia in the tumors. Tumor growth delay was used to assess the response of the subcutaneous tumor to the various treatment combinations. There was a strong correlation between increased therapeutic response and decreased tumor hypoxia. Tumor growth delay from BCNU increased from 5.3 days to 16.4 days with TNP-470/-minocycline/hemoglobin solution/carbogen. Similarly, the tumor growth delay from adriamycin increased from 3.9 days to 17.0 days with TNP-470/minocycline/hemoglobin solution/carbogen. Finally, the tumor growth delay from fractionated radiation increased from 4.8 days to 13.3 days with TNP-470/minocycline/hemoglobin solution/carbogen. When etanidazole was added to the complete radiation regimen, the tumor growth delay increased further to 20.5 days. These data show that the addition of non-toxic agents that increase tumor oxygenation to cytotoxic therapies can markedly increase therapeutic response.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7669943&dopt=Abstract
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