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J Antimicrob Chemother. 1995 May;35(5):687-90.
Antimicrobial susceptibility of penicillin-sensitive and penicillin-resistant meningococci.

Abadi FJ, Yakubu DE, Pennington TH.

Department of Medical Microbiology, University of Aberdeen Medical School, Foresterhill, UK.

Ceftriaxone showed high in-vitro activity against 119 penicillin-sensitive, penicillin-resistant and rifampicin-resistant UK isolates of meningococci. Unlike ciprofloxacin and minocycline, ceftriaxone is suitable for use in young children or in pregnancy and should be considered for therapy or prophylaxis in an outbreak of meningococcal disease. The E test gave results comparable to those given by broth microdilution method in the determination of meningococcal susceptibility to antimicrobials. It is convenient for use in small laboratories and can be used to determine antimicrobial subgroups of meningococci.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7592183&dopt=Abstract




Kansenshogaku Zasshi. 1995 Aug;69(8):895-902.
[Bacteremia with Acinetobacter species--clinicopathological characteristics of 27 cases]

[Article in Japanese]

Kurosu I.

First Department of Internal Medicine, Nihon University School of Medicine.

Acinetobacter spp. are non-fermented gram-negative rods that are widespread in the environment and colonize in the human skin. They are known to be a nosocomial pathogen causing, pneumonia, meningitis and bacteremia. Recently, they have been found increasingly in catheter-related infections (CRI). Thirty-seven cases of bacteremia were developed in our hospital during the past five years. Of these 27 cases were chosen out of the medical records for discussion in this paper. Twenty-three cases are blood positive for Acinetobacter anitratus and 4 cases for A. lwoffii. Most cases have an underlying disease like hematological malignancy, solid tumor and infantile congenital abnormality. There were also some clinical signs; high fever, hypotension, tachycardia, tachypnea, peripheral cyanosis. A central venus catheter was inserted in 22 cases, and in 13 of these, the catheter was removed after the bacteremic episode. Nine cases became afebrile after the removal of the catheter and A. anitratus was isolated from the catheter tip in four cases. Heparin was administered through the catheter in 7 cases. Formerly Acinetobacter spp. were not recognized as a major pathogen, but recently found increasingly in CRI. We also found 9 cases which were definitely diagnosed or suspected as CRI, and were successfully treated by removal of the central venus catheter. Association between administration of heparin and bacteremia of Acinetobacter spp. was reported, we actually detected such association in 7 cases, but the potential role of heparin has not been clarified yet. Compared with A. lwoffii, A. anitratus were resistant to many drugs, but had good susceptibility to imipenem, minocycline, aminoglycoside, and fluoroquinolone.(ABSTRACT TRUNCATED AT 250 WORDS)

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7594782&dopt=Abstract




Zhonghua Yi Xue Za Zhi. 1995 Jan;75(1):11-4, 60.
[Susceptibility study on urogenital Chlamydia trachomatis to 19 kinds of antibiotics]

[Article in Chinese]

Bai H, Dong J, Ning B.

Department of Dermatology, First Affiliated Hospital Sun Yat-San University of Medical Sciences, Guangzhou.

We detected the minimal inhibitory concentrations (MIC) and minimal bacteriocidal concentrations (MBC) of 19 kinds of antibiotics against urogenital chlamydia trachomatis (CT) from sexually transmitted disease (STD) patients. The results were as follows: (1) The mean MICs of tetracycline, doxycycline, minocycline, erythromycin, josamycin, medimycin, lomexacin and ofloxacin were lower than 0.08 microgram/ml. Clindamycin was lightly inhibitant to CT. Steptomycin, cephaloradine, chloramiphonic, metronidazole, ciprofloxacin, sulfamethaxazole and trimethoprim showed no activitis to urogenital CT. (2) The values of the MICs and MBCs of the standard strains were among those of the isolated ones. Another the differences in drug susceptibility of different serovars were observed. (3) The MIC detected method is also discussed.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7600311&dopt=Abstract












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