Drugs online research references
Vet Microbiol. 1995 Aug;45(4):331-7.
Tetracycline resistance determinants among streptococci of serological group G and L.
Soedarmanto I, Schwarz S, Liebisch B, Lammler C.
Institut fur Kleintierforschung Celle/Merbitz der Bundesforschungsanstalt fur Landwirtschaft, Braunschweig-Volkenrode (FAL), Germany.
In the present study 56 streptococci of serological group G and L isolated from various animal species and from humans were investigated for tetracycline and minocycline resistance and for the presence of genes conferring this combined resistance. Among the 45 group G streptococci, 2 isolates from dogs, 3 from cattle and 2 from humans, respectively, as well as all 11 group L streptococci isolated from cattle, pigs or poultry were resistant to tetracycline and simultaneously to minocycline. The restriction endonuclease digested and blotted DNA-preparation of the tetracycline-and minocycline resistant group G streptococci from dogs and humans hybridized with the tet (M) gene probe, those from bovines with the tet (O) gene probe. Six group L streptococci carried the gene tet (M), whereas 5 isolates harboured the gene tet (O). The tet (M)-and tet (O) gene probes recognized complementary sequences on EcoRI-fragments of various sizes.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7483246&dopt=Abstract
Zentralbl Veterinarmed B. 1995 Mar;42(1):42-50.
Characteristic properties of streptococci of serological group L.
Sippel K, Dulffer-Schneitzer B, Lammler C.
Institut fur Bakteriologie und Immunologie, Justus-Liebig-Universitat Giessen, Germany.
This study was designed to characterize further 88 streptococci of serological group L, isolated from bovines, pigs, poultry and humans. Most group L streptococci from bovines grew as granular sediment with long chains in fluid media and with compact colonies in soft agar. Most group L streptococci from pigs grew with a uniform turbidity in fluid media, short chains, and with diffuse colonies in soft agar. The biochemical characteristics, determined with the Strepzym identification system, revealed no significant differences between the group L streptococci of various origins. A positive opacity factor reaction could mainly be observed with group L streptococci from bovines and humans, but was less pronounced with group L streptococci from pigs and poultry. In addition, 27 group L streptococci reacted with type antigen X or R and 9 cultures with M1 or M6 specific antiserum. The determination of antibiotic resistance patterns revealed that all group L streptococci were resistant to tetracycline and minocycline, part of the cultures were resistant to chloramphenicol, erythromycin and gentamicin, and all cultures were susceptible to penicillin, bacitracin, cefoxitin and nitrofurantoin. All these data allowed an individual characterization of group L streptococci, possibly useful for epidemiological studies.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7483900&dopt=Abstract
Antimicrob Agents Chemother. 1995 Aug;39(8):1864-5.
Susceptibilities of Neisseria gonorrhoeae to the glycylcyclines.
Whittington WL, Roberts MC, Hale J, Holmes KK.
Department of Medicine, University of Washington, Seattle 98195, USA.
To assess the activities of two glycylcyclines, N,N-dimethylglycylamido (DMG) derivatives of minocycline (MINO) and 6-demethyl-6-deoxytetracycline (DMDOT), 203 gonococcal isolates recovered at six sexually transmitted disease clinics in the western United States were evaluated. Antimicrobial susceptibilities to tetracycline HCl, doxycycline, MINO, DMG-DMDOT, and DMG-MINO were determined by agar dilution tests. DMG-DMDOT and DMG-MINO were more active than tetracycline HCl, doxycycline, or MINO regardless of the presence of Tet M or of chromosomal mutations mediating tetracycline resistance (P < 0.001).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7486935&dopt=Abstract
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