Drugs online research references
Arch Gynecol. 1981;230(4):329-33.
Isolation of Chlamydia trachomatis from women with urethral syndrome.
Weil A, Gaudenz R, Burgener L, Schultz B.
Urethral swabs were examined for Chlamydia trachomatis in 22 women suffering from urethral syndrome and in an age-matched control group without genito-urinary symptoms. Full urodynamic investigation was done in patients with urinary symptoms. In this group the isolation rate of C. trachomatis was significantly higher than in the control group (59% versus 13%, P less than 0.01). Therefore C. trachomatis must be considered as one of the possible causes of the female urethral syndrome. Five out of eight patients with positive culture who were treated with minocycline had a negative follow-up culture and the clinical results of this treatment were variable.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7283481&dopt=Abstract
Antimicrob Agents Chemother. 1981 Nov;20(5):610-2.
Susceptibility of Mycobacterium marinum to tetracyclines and aminoglycosides.
Wallace RJ Jr, Wiss K.
Current agar dilution methods for susceptibility testing of Mycobacterium marinum versus the tetracyclines have failed to show in vitro susceptibility despite good in vivo results. We found that the tetracyclines were unstable in agar and resulted in a fine haze of growth for several concentrations before complete inhibition of growth was seen. In contrast, the aminoglycosides resulted in sharp minimal inhibitory concentration endpoints, which were generally independent of the length of incubation. The problems with the tetracyclines can be lessened by shortening the incubation time to 5 days and redefining the minimal inhibitory concentration as the lowest concentration resulting in no growth or a slight haze of growth. By this methodology, 19 clinical isolates of M. marinum were tested for susceptibility to the tetracyclines and aminoglycosides. Minocycline inhibited greater than 50% of isolates at 2.0 microgram/ml, whereas both minocycline and doxycycline inhibited greater than 90% of isolates at 4.0 microgram/ml. These studies support the usage of the tetracyclines in the treatment of clinical diseases due to M. marinum and suggest a susceptibility method which is more predictive of clinical results.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7325629&dopt=Abstract
J Toxicol Sci. 1981 Nov;6(4):261-70.
Studies on nitrosamine formation by the interaction between drugs and nitrite. I. Measurement of the amount of nitrosamine formed in rat and guinea pig stomachs.
Kawanishi T, Ohno Y, Takahashi A, Ishiwata H, Tanimura A, Kasuya Y, Omori Y.
The amounts of nitrosamine formed by the interaction of several drugs and nitrite in rat and guinea pig stomachs were estimated. The nitrosamine formation from aminopyrine and nitrite was much more in guinea pig stomachs than in rat stomachs. It seemed that this result was due to the difference in gastric contents of these animals. As the nitrosamine formation was also indicated in the interaction of a clinically prescribed dose of aminopyrine and very low doses of nitrite in rat and guinea pig stomachs, there is a possibility that the nitrosation of aminopyrine takes place in human stomachs, too. Minocycline also interacted with nitrite and formed N-nitrosodimethylamine. However, the amount of nitrosamine formed was less in minocycline than in aminopyrine. Oxytetracycline was not found to form nitrosamine in the stomachs of these animals. The effects of several compounds on the nitrosamine formation by the interaction of aminopyrine and nitrite were also investigated. Ascorbic acid, sodium erythorbate, propyl gallate and butylated hydroxyanisole reduced the nitrosamine formation but the effect of alpha tocopherol, sorbic acid and butylated hydroxytoluene was not observed in the stomach.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7338958&dopt=Abstract
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