Drugs online research references
Arzneimittelforschung. 1980;30(12):2093-8.
Susceptibility of Bacteroides fragilis, Bacteroides thetaiotaomicron, and Fusobacteria in Antibacterial agents.
Niederau W, Hoffler U, Pulverer G.
The minimum inhibitory concentrations of 45 antimicrobial agents were established by the agar dilution method for 37 strains of Bacteroidaceae: Bacteroides fragilis (18 strains), B. thetaiotaomicron (8 strains), Fusobacterium nucleatum (6 strains), and Fusobacterium spp. (5 strains). The fusobacteria tested showed good susceptibility to beta-lactam-antibiotics, tetracyclines, lincomycins, and nitroimidazole compounds. Bacteria of the B. fragilis group were resistant to most of the penicillins and cephalosporins and could not be suppressed with certainty by nitroimidazoles and older tetracyclines. Doxycycline and minocycline, however, showed sufficient activity, and all our Bacteroides strains tested were sensitive to clindamycin. Especially the good in vitro susceptibility of all Bacteroidaceae strains investigated to cefoxitin may offer new therapeutic possibilities.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7194067&dopt=Abstract
Arzneimittelforschung. 1981;31(5):764-70.
Susceptibility of the species of genus bacteroides recently isolated from clinical specimens to 20 antimicrobial agents.
Nasu M, Nakatomi M, Saito A, Hara K.
Susceptibility of 105 strains of bacteroides species (including 82 strains of B. fragilis, 8 strains of B. distasonis, 5 strains of B. thetaiotaomicron, 4 strains of B. vulgatus, 3 strains of B. ovatus and 3 other strains) isolated from patients to chemotherapeutic agents was determined by an agar dilution technique. Good to excellent inhibition rates (75--100% of strains) were found for carbenicillin, ticarcillin, piperacillin, apalcillin, minocycline, chloramphenicol, thiamphenicol, rifampicin, erythromycin, clindamycin, and lincomycin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7196732&dopt=Abstract
J Urol. 1977 Oct;118(4):609-11.
Minocycline diffusion into benign prostatic hyperplasia.
Hensle TW, Prout GR Jr, Griffin P.
Minocycline, a broad-spectrum, highly lipid soluble tetracycline that has generated interest in the treatment of chronic prostatitis, was evaluated for its possible ability to be concentrated in benign prostatic hyperplasia. Drug levels in the prostate, plasma, fat, muscle and urine were measured in patients undergoing open prostatectomy after preoperative intravenous minocycline. The concentrations of the drug in the prostate and serum were close (4.16 versus 3.01 microgram. per gm.), while drug levels in striated muscle and fat were consistently lower (2.92 and 0.77 microgram. per gm). Higher preoperative doses of drug yielded higher tissue levels. Drug delivery closer temporally to the operation yielded higher serum and prostatic levels as opposed to striated muscle and fat, suggesting a rapid diffusion of the drug into benign prostatic hyperplasia.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=72165&dopt=Abstract
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