Drugs online research references
J Infect Dis. 1978 Nov;138(5):655-9.
Prediction of efficacy of antimicrobial agents in treatment of infections due to Chlamydia trachomatis.
Bowie WR, Lee CK, Alexander ER.
Although Chlamydia trachomatis is readily eradicated by systemic therapy in patients with acute urethritis, systemic therapy is less satisfactory in treatment of chronic trachoma. The activities of antimicrobial agents against C. trachomatis in cell cultures when the antimicrobial agents are added 1 hr after the C. trachomatis (minimal inhibitory concentration [MIC]) predicts efficacy of the drugs in the treatment of urethritis but does not necessarily predict efficacy in the treatment of chronic ocular trachoma. Concentrations of antimicrobial agents required to eradicate C. trachomatis when the agents were added 48 hr after inoculation of the cell cultures with C. trachomatis exceeded the MIC by several logarithms, and minocycline, doxycycline, and rifampin were markedly more active than tetracycline, erythromycin, or several other antimicrobial agents. Of the three most active antimicrobial agents, only doxycycline has been used systemically to treat ocular infections due to C. trachomatis, and it has been reported to be the most effective antimicrobial agent that has been utilized. In vitro testing of obligate intracellular pathogens such as C. trachomatis presents unique problems. Utilization of several methods of testing may help to identify antimicrobial agents with improved clinical efficacy, particularly in the treatment of ocular trachoma.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=712119&dopt=Abstract
Jpn J Antibiot. 1982 May;35(5):1233-9.
[Susceptibilities of Pseudomonas species to aminoglycosides and tetracyclines]
[Article in Japanese]
Igari J, Kosakai N, Oguri T.
Pseudomonas aeruginosa has attracted much attention through its role in hospital outbreaks of disease. However, other members of the genus Pseudomonas, particularly Pseudomonas maltophilia and Pseudomonas cepacia, may be isolated as opportunistic pathogens of man, and can be found in hospital materials. These organisms have been less susceptible to the commonly used antibiotics. This report deals with the in vitro sensitivity of Pseudomonas strains except for P. aeruginosa to aminoglycosides and tetracyclines. The following bacteria were tested: P. maltophilia (50 strains), P. fluorescens (29 strains), P. putida (52 strains), P. cepacia (49 strains), P. putrefaciens (18 strains), P. acidovorans (12 strains). All of the strains for this study were isolated from routine cultures of infected clinical materials which sent to the Clinical Laboratories, Juntendo University Hospital during the 1 year period of 1980. The tests for susceptibility of the strains to the 3 aminoglycosides (gentamicin, tobramycin, amikacin) and 3 tetracyclines (tetracycline, doxycycline, minocycline) were all performed by the serial 2-fold agar plate dilution method on heart infusion agar, standardized by the Japan Society of Chemotherapy, using the microplanter apparatus with an inoculum size of approximately 10(8) CFU/ml. There were similar sensitivity patterns for the aminoglycosides tested; most of the strains of P. maltophilia, P. cepacia and P. acidovorans were resistant to the aminoglycosides, while most of P. fluorescens, P. putida and P. putrefaciens were sensitive. Minocycline and doxycycline were extremely active to the Pseudomonas species studied. Tetracycline was almost ineffective against P. maltophilia and P. cepacia.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7131756&dopt=Abstract
Ann Rech Vet. 1982;13(2):199-204.
[Effect of route and place of minocycline administration on the zootechnical performance of rabbits]
[Article in French]
Camguilhem R, Escoula L, Larrieu G.
Minocycline administered to rabbits per os or intramuscularly (30 mg/kg) over a period of three days led neither to digestive problems nor mortality. Administration per os left the growth curve unchanged. Intramuscular administration reduced rate of growth, and on the 15th day weight loss compared to controls was 3.2% or 11.7% depending on whether the place of administration was in the back muscles or in the thigh, and this despite a normal food intake. Minocycline did not modify microbial flora and level of ammonia in the caecum. Level of acetic acid was reduced by 50% on the fourth and 15th day after intramuscular administration of minocycline into the thigh. The depressive effect of minocycline on growth remains unexplained.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7168542&dopt=Abstract
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