Drugs online research references
Jpn J Antibiot. 1980 May;33(5):623-35.
[Studies on the distributions of antibiotics in the oral tissues: Experimental staphylococcal infection in rats, and effect of serratiopeptidase on the distributions of antibiotics (author's transl)]
[Article in Japanese]
Aratani H, Tateishi H, Negita S.
1) A focal infection was prepared by inoculation of staphylococci into rat gingiva. Then, concentrations in oral tissues (gingiva, tongue and masseter), serum and liver of the infected rats which were given ciclacillin, ampicillin, cephalexin and minocycline in a dose of 100 mg/kg p.o. were investigated and effects of serratiopeptidase (20 mg/kg) on these concentrations were studied. 2) Concentrations of ciclacillin in the oral tissues were approximately 10% of a serum level. A gingival concentration was elevated 8.5-fold by pretreatment with serratiopeptidase. A concentration in infected gingiva was 2.5-fold of that of another side of gingiva. 3) Concentrations of ampicillin in the oral tissues were approximately 15% of a serum level. A gingival concentration was elevated 5.7-fold by pretreatment with serratiopeptidase. A concentration in infected gingiva ws 2.2-fold of that of another side of gingiva. 4) Concentrations of cephalexin in the oral tissues were approximately 3 to 5-fold of a serum level except that in masseter. A gingival concentration was slightly elevated (1.1-fold) by pretreatment with serratiopeptidase. A concentration in infected gingiva was 1.7-fold of that of another side of gingiva. 5) Concentrations of minocycline in the oral tissues were 1.3 to 7.2-fold of a serum level. A gingival concentration was elevated 2.2-fold by pretreatment with serratipeptidase. A concentration in infected gingiva was 3.1-fold of that of another side of gingiva. 6) Gingival concentrations of antibiotics were higher than those of tongue and masseter and serratiopeptidase elevated gingival concentrations.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7001087&dopt=Abstract
J Gen Microbiol. 1980 Nov;121(1):221-9.
Evidence for more than one mechanism of plasmid-determined tetracycline resistance in Escherichia coli.
Shales SW, Chopra I, Ball PR.
The basis of tetracycline resistance mediated by TetA determinants and joint resistance to tetracycline and minocycline coded by TetB determinants was investigated. The TetA class of determinants was represented by those carried on plasmids pSC101, RP1 and pIP7 and TetB by Tn10. The relationships between expression of tetracycline and minocycline resistance and accumulation of these antibiotics suggest that there are three mechanisms of plasmid-determined resistance conferring (1) about a 10- to 20-fold increase in resistance to tetracycline that is not associated with decreased antibiotic accumulation, (2) a 4- to 7-fold increase in resistance to tetracycline that is associated with decreased drug accumulation, and (3) about a 2- to 3-fold increase in resistance to both tetracycline and minocycline that is not associated with decreased accumulation of either antibiotic. Mechanism 1 was coded by the tetracycline resistance determinant of pSC101 (TetA), mechanisms 1 and 2 by the determinants in RP1 and pIP7 (TetA) and all three mechanisms by Tn10 (TetB).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7019387&dopt=Abstract
Med J Aust. 1982 May 29;1(11):459-61.
Antibiotic susceptibility of Staphylococcus aureus community acquired strains.
Mutton KJ, Andrew JH.
Over 250 strains of Staphylococcus aureus isolated from patients who presented with infections acquired outside the hospital were tested for susceptibility to penicillin G, minocycline and erythromycin. Only 15.5% of strains could be regarded as sensitive to penicillin, whereas 99.2% and 90.2% were sensitive to minocycline and erythromycin respectively. Beta-haemolytic streptococci were found in association with Staph. aureus in 17.5% of the lesions cultured in this survey. The susceptibility of a further 100 strains of methicillin-sensitive Staph. aureus to a wider range of antimicrobial agents was also examined.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7048038&dopt=Abstract
online pharmacies ||
Hair Million herbal formula for hair loss and hair growth ||
Amoxicillin ||
Tramadol ||
Paxil ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Zithromax ||
online pharmacy ||
Antibiotics and prescription medications online literature ||
Antibiotics