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Antibiotiki. 1981 Jan;26(1):55-8.
[Effect of antibiotics on human lymphocyte mitogenesis]

[Article in Russian]

Rachkov SM, Bekbergenov BM, Korolev PN, Glezer GA.

The effect of some antibiotics on in vitro blast transformation of lymphocytes of healthy donors stimulated with phytohemagglutinin was studied. The stimulation level was estimated by incorporation of 3H-thymidine into lymphocytes. It was shown that minocycline had a markedly pronounced inhibitory activity. Chloramphenicol and tetracycline also proved to be active inhibitors. Penicillin, cephalotin and carbenicillin had no effect on lymphocyte mitogenesis. Gentamicin proved to be a rather active stimulator of mitogenesis, especially with the use of a suboptimal concentration of phytohemagglutinin. The method is rather sensitive and informative. It may be used for preliminary determination of the immunotropic properties of drugs and chemical compounds with respect to immunocompetent cells of man.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6971073&dopt=Abstract




Ann Microbiol (Paris). 1978 May-Jun;129(4):503-7.
Antimicrobial susceptibility of rhamnose-positive Yersinia enterocolitica.

Dabernat HJ.

Agar dilution antimicrobial susceptibility tests were carried out against rhamnose-positive Y. enterocolitica strains isolated from various origins. All the strains were susceptible to aminoglycosides, chloramphenicol, tetracycline, minocycline, rifampicin, trimethprim and sulfamethoxazole. All but two strains were susceptible to polymyxin. Resistnace to ampicillin, carbenicillin and cephalothin was noted with the majority of the strains.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=697262&dopt=Abstract




Antimicrob Agents Chemother. 1982 Mar;21(3):498-500.
Emergence of rifampin-resistant Haemophilus influenzae.

Nicolle LE, Postl B, Kotelewetz E, Albritton W, Harding GK, Bourgault AM, Ronald AR.

Rifampin susceptibility of nasopharyngeal Haemophilus influenzae strains was determined before and after community-wide chemoprophylaxis with rifampin (children) and sequential minocycline-rifampin (adults). All strains were rifampin susceptible before prophylaxis, but 10.3% of the strains at 1 week and 7.5% of the strains at 9 weeks after prophylaxis were rifampin resistant.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6980623&dopt=Abstract













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