Drugs online research references
Antimicrob Agents Chemother. 1980 Jul;18(1):9-12.
In vitro antimicrobial susceptibility of Actinobacillus actinomycetemcomitans.
Slots J, Evans RT, Lobbins PM, Genco RJ.
The agar dilution technique was used for determination of the antibiotic susceptibilities of 57 oral isolates and 2 nonoral isolates of Actinobacillus actinomycetemcomitans. Tetracycline, minocycline, and chloramphenicol inhibited more than 96% of the strains tested at a concentration of less than or equal to 2 micrograms/ml; 89% of the strains were inhibited by 2 micrograms of carbenicillin per ml. The other antimicrobial agents tested were less active. Approximately 10% of the A. actinomycetemcomitans strains were resistant to ampicillin, erythromycin, and penicillin G at concentrations of 32 to 64 micrograms/ml. These data suggest that tetracycline and minocycline may be valuable drugs in the treatment of A. actinomycetemcomitans infections.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6903116&dopt=Abstract
Antimicrob Agents Chemother. 1982 Aug;22(2):186-92.
Rapidly growing mycobacteria: testing of susceptibility to 34 antimicrobial agents by broth microdilution.
Swenson JM, Thornsberry C, Silcox VA.
A total of 18 strains of Mycobacterium fortuitum, 15 strains of M. chelonei, and 31 strains of M. chelonei-like organisms were tested by both broth microdilution and agar dilution to determine their susceptibility to 34 antimicrobial agents. All strains grew well enough in cation-supplemented Mueller-Hinton broth for endpoints to be read after 72 h of incubation. Some strains of M. chelonei did not grow on Mueller-Hinton agar. A few discrepancies were noted between the broth and agar procedures. For M. fortuitum, doxycycline, minocycline, amikacin, sulfamethoxazole, and sulfamethoxazole-trimethoprim were the most active agents. For M. chelonei, amikacin, sisomicin, tobramycin, and erythromycin were the most active agents. The M. chelonei-like organisms were most susceptible to ampicillin, doxycycline, minocycline, amikacin, erythromycin, sulfamethoxazole, and sulfamethoxazole-trimethoprim. Broth microdilution appears to be a reliable method for susceptibility testing of rapidly growing mycobacteria, although clinical studies are needed to determine how well in vitro results correlate with therapeutic in vivo outcome.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6927280&dopt=Abstract
Pharmacol Ther Dent. 1981;6(1-2):45-56.
In vitro evaluation of antibiotics in the treatment of periodontal disease.
Mashimo PA, Yamamoto Y, Slots J, Evans RT, Genco RJ.
To assess the antibiotic sensitivity of subgingival microflora, chloramphenicol sodium succinate, clindamycin hydrochloride hydrate, disodium carbenicillin, doxycycline hyclate, erythromycin, minocycline hydrochloride, penicillin -G, spiramycin adipate, tetracycline hydrochloride and metronidazole were examined. Eleven patients with periodontitis were selected for sampling. Subgingival plaque samples were taken from three sites on each patient. Anaerobic incubation of the plaque samples for ten days was made on the blood agar plates which contained 0.1 microgram/ml and 5 microgram/ml of each antibiotic substance, respectively. According to the results of viable counts on the plates, it was determined that penicillin, tetracycline, doxycycline, and minocycline were most effective antibiotics with which to control the periodontal plaque organisms. Resistant organisms against those four antibiotics were generally Streptococcus species. "anaerobic vibrios", and Veillonella parvula. Some of the oral anaerobic isolates were also tested against all antibiotics at the concentration of 1 microgram/ml of each. Minocycline and clindamycin were the two most effective antibiotics against anaerobic subgingival purified strains and chloramphenicol was the least effective.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6941319&dopt=Abstract
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