Drugs online research references
Chemotherapy. 1980;26(3):196-206.
A murine model for listerial meningitis and meningoencephalomyelitis: therapeutic evaluation of drugs in mice.
Tsai YH, Hirth RS, Leitner F.
Meningitis and meningoencephalomyelitis caused by Listeria monocytogenes were experimentally established in mice. The pathological changes in brain and spinal cord resulting from the infection resemble those observed in man and domestic animals. The efficacy of 24 antibiotics in treating this experimental infection was determined. Minocycline and chlortetracycline were the most efficacious antiotics followed by amoxicillin, which was 2- to 4-fold less active than the former. However, the acute toxicity of amoxicillin to the murine central nervous system was at least 10-fold lower than that of the tetracyclines. Since parenteral amoxicillin may be of value in the management of listerial meningitis and meningoencephalomyelitis in man and domestic animals, clinical trials seem warranted.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6767585&dopt=Abstract
Jpn J Antibiot. 1980 Jun;33(6):668-74.
[Susceptibility of Pseudomonas aeruginosa recently isolated from clinical specimens to various antimicrobial agents and changes of susceptibility to carbenicillin, gentamicin and amikacin (author's transl)]
[Article in Japanese]
Kosakai N, Oguri T.
We estimated the minimum inhibitory concentrations of following twenty-one antimicrobial agents against 161 strains of Pseudomonas aeruginosa isolated from clinical specimens during 1979. Antimicrobial agents were 5 penicillins (carbenicillin, sulbenicillin, piperacillin, apalcillin and ticarcillin), 3 cephalosporins (cefsulodin, cefoperazone and ceftizoxime), 5 aminoglycosides (gentamicin, tobramycin, dibekacin, amikacin and kanamycin), 3 tetracycclines (tetracyline, doxycycline and minocycline), chloramphenicol, colistin, polymyxin B, nalidixic acid and pipemidic acid. Among penicillins piperacillin and apalcillin showed strongest antibacterial activity and the activity of carbenicillin was weakest. Highly resistant strains against carbenicillin increased rapidly until 1975. Among cephalosporins cefsulodin showed strongest antibacterial activity and its activity was stronger than piperacillin. Antibacterial activity of cefoperazone and ceftizoxime were weaker than cefsulodin, but stronger than carbenicillin and sulbenicillin. Among aminoglycosides kanamycin showed very weak antibacterial activity, but another four drugs showed very strong activity. But resistant strains against these four drugs increased gradually and over 20% of strains was resistant to gentamicin. Among gentamicin, tobramycin and dibekacin cross-resistance was observed, but not between amikacin and these three drugs. Recently the number of strains resistant to both amikacin and gentamicin increased. Tetracyclines, chloramphenicol and nalidixic acid showed rather weak activity, but colistin and polymyxin B showed very strong activity and resistant strains against these drugs were very few. Pipemidic acid showed rather stronger activity than nalidixic acid, but its activity was weaker than aminoglycosides excluding kanamycin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6779031&dopt=Abstract
N Z Med J. 1980 Nov 26;92(672):380-2.
Antimicrobial susceptibility of Neisseria meningitidis isolated from 1975-1979.
Green MJ, Cawley PF.
During the period 1975 to 1979, 88 isolates of Neisseria meningitidis from cerebrospinal fluid (CSF), 28 isolates from blood, and 89 isolates from other sources were serogrouped and tested for their susceptibility to sulphadiazine, penicillin, minocycline and rifampin. Prior to 1979, isolates from CSF or blood were predominantly serogroup B. In the sample tested, the prevalence of this serogroup decreased while the prevalence of serogroup A isolates increased, until in 1979 this was the predominant serogroup. From 1975, the incidence of sulphonamide-resistance in the serogroup B isolates from CSF or blood decreased. However, all serogroup A isolates from these sources, except the first one tested, were sulphonamide-resistant. The 89 isolates from other sources remained predominantly sulphonamide-sensitive serogroup B. All isolates were sensitive to penicillin, minocycline and rifampin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6782526&dopt=Abstract
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