Drugs online research references
Gann. 1984 Mar;75(3):245-52.
Formation of volatile nitrosamines by drug-nitrite interactions under physiological conditions.
Sakai A, Inoue T, Tanimura A.
Twenty-eight drugs, most of which are tertiary amines, were tested for the formation of volatile nitrosamines by reaction with nitrite under physiological conditions; the drugs (10mM) were incubated with nitrite ( 40mM ) at pH 3.0, 37 degrees for 1 and 4 hr. The volatile nitrosamines formed were determined by gas chromatography-thermal energy analysis. Of the 28 drugs, 24 formed measurable amounts of volatile nitrosamines that are known carcinogens. The yields of nitrosodimethylamine (NDMA) from aminopyrine (55-65%) and minocycline (11%) were higher than that from dimethylamine under the same conditions. This result suggests that there may be a pathway not involving the secondary amine (dimethylamine) as an intermediate in the formation of NDMA from minocycline as well as from aminopyrine, Tolazamide gave rise to nitrosopiperidine ( NPIP ) in addition to nitrosohexamethyleneimine ( NHXI ), formation of which was expected from the chemical structure of tolazamide, and the yield of NPIP (2-7%) was higher than that of NHXI (0.2-1.2%). Ascorbic acid ( 40mM ) was effective in decreasing the formation of nitrosamines from drugs by reaction with nitrite, although the blocking effects varied between 88 and 100% depending on the drugs tested or on the nitrosamines formed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6724228&dopt=Abstract
J Antibiot (Tokyo). 1984 Apr;37(4):401-7.
Timed bacteriostatic and bactericidal activities of selected antimicrobial agents against Bacteroides fragilis isolated from clinical specimens.
Masuda G.
The activities of selected antimicrobial agents were evaluated for bacteriostatic and bactericidal activities for a large number of clinically obtained strains of Bacteroides fragilis, with special reference to the incubation time of the microbes with the drugs. If the mode of action of a drug is categorized as bactericidal when the ratio of bactericidal concentration/bacteriostatic concentration is low (less than or equal to 4), and as bacteriostatic when high (greater than or equal to 8), during given periods of incubation, then clindamycin, minocycline and chloramphenicol appeared to be bacteriostatic, and cefoxitin, cefmetazole, latamoxef (moxalactam) and metronidazole bactericidal, when the incubation time was brief (6 hours). All these drugs acted bactericidally on most of the test strains, if the time of incubation was prolonged to 24 hours.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6725144&dopt=Abstract
J Pharm Pharmacol. 1976 May;28(5):420-3.
Fluorimetric assay of tetracycline mixtures.
Hall D.
A simple and precise fluorimetric method is described for the simultaneous assay in plasma of a mixture containing chlortetracycline, demethylchlortetracycline and tetracycline. Assay within the therapeutic ranges of 0-5 mg litre(-1) is achieved by formation of strongly fluorescent aluminum/tetracycline complexes, without prior extraction or separation of the individual antibiotics. This is performed by determinations at the peak excitation and fluorescence emission wavelengths of each tetracycline chelate. The method can be similarly applied to the assay of oxytetracycline, rolitetracycline and minocycline.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6750&dopt=Abstract
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