Drugs online research references
Jpn J Antibiot. 1983 Oct;36(10):2750-6.
[Bacterial species recently isolated from urinary tract infections and their antibiotic susceptibility, with special reference to acute cystitis]
[Article in Japanese]
Arai T, Suzuki K.
Numbers of the strains of each bacterial species isolated from urinary tract infections were summed and their incidences were calculated for each a half year from the second half of 1980 to the first half of 1982. The incidences of Escherichia coli strains were found to be greatly reduced and those of Streptococcus faecalis strains were greatly increased. Those of Staphylococcus epidermidis strains were also increased. This trend was thought to be caused by the extensive and exclusive use of cephalosporin derivatives. Minimal inhibitory concentrations of gentamicin (GM), amikacin (AMK), ampicillin (ABPC), cefazolin (CEZ), ceftizoxime (CZX), latamoxef (LMOX) and minocycline (MINO) against these isolated strains were estimated. The most sensitive drugs for E. coli were found to be CZX, LMOX, GM and AMK, CZX and MINO for Klebsiella, CZX and LMOX for Proteus, and GM for Pseudomonas aeruginosa. All Gram-positive cocci were found generally to be most susceptible to MINO, but S. faecalis and other Pseudomonas were also sensitive to ABPC. Exclusive use of cephalosporins for the treatment may induce selective increases of the resistant species in normal flora. Since these flora could be the causative agents for various infections, these selections caused by the exclusive use of the monotype drugs are not preferable, and various different drugs should be used for the suitable cases.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6674515&dopt=Abstract
J Reprod Med. 1984 Feb;29(2):81-7.
Minocycline prophylaxis in elective hysterectomy.
Savage EW, Thadepalli H, Rambhatla K, Roy I, Davidson EC Jr.
Minocycline prophylaxis was compared with a placebo in 126 consecutive patients undergoing hysterectomy. The double-blind nature of this study was guarded until the study was completed. Of 95 patients who had abdominal hysterectomies, 32.7% on minocycline and 39.1% on placebo developed infectious complications. Of 31 vaginal hysterectomy patients, 20% on minocycline and 37.5% on the placebo developed septic complications (p less than 0.05). Although minocycline inhibited B. fragilis and E. coli effectively, those organisms colonized increasingly during the postoperative period with similar frequency in both the minocycline- and placebo-treated groups. Minocycline did not produce antibiotic-resistant strains. In our study the parenteral and oral forms of minocycline were found to be safe, and vestibular symptoms were no more common than in the placebo group. These data suggest that antibiotic prophylaxis with minocycline is safe and well tolerated. In addition, minocycline is effective in lowering the infection rate in vaginal, but not abdominal, hysterectomies.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6708031&dopt=Abstract
J Urol. 1978 Aug;120(2):184-5.
Trimethoprium-sulfamethoxazole and minocycline- hydrochloride in the treatment of culture-proved bacterial prostatitis.
Paulson DF, White RD.
Trimethoprim-sulfamethoxazole, 2 tablets twice daily for 90 days, or minocycline-hydrochloride, 100 mg. twice daily for 14 days, was given to 15 and 14 men, respectively, with culture-proved bacterial prostatitis. Given as prescribed both agents seemed equally effective in controlling symptomatic recurrence during the 12 months after cessation of therapy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=671629&dopt=Abstract
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