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J Int Med Res. 1984;12(6):364-8.
Phage-types and susceptibility to 26 antibiotics of nosocomial strains of Acinetobacter isolated in Portugal.

Santos Ferreira MO, Vieu JF, Klein B.

Sixty-two strains of Acinetobacter calcoaceticus isolated from pathological samples or from the environment in several hospitals in Lisbon, were studied by means of two complementary phage-typing systems. Eighteen phage-types or sub-types, one group of uncommon types (9.6%) and one group of untypable strains (20.9%) were found. A new phage-type (No. 104) and a new sub-type (No. 18) were defined among the Portuguese strains. The in vitro activity of 26 antibiotics against 48 nosocomial strains was studied by the Kirby-Bauer method. The most active antibiotics were, in decreasing order, amikacin, carbenicillin, tobramycin, minocycline, dibekacin, doxycycline, sisomycin, trimethoprim-sulphamethoxacole, ticarcillin and piperacillin. The strains were also tested against 4 new beta-lactam antibiotics, and the MICs were determined by an agar dilution method. N-formimidoyl-thienamycin was found to be the most active against Acinetobacter and ceftazidime was considerably more active than apalcillin and cefotaxime.

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Am J Vet Res. 1984 Dec;45(12):2631-3.
Susceptibility of Bacteroides from swine abscesses to 13 antibiotics.

Benno Y, Mitsuoka T.

The minimal inhibitory concentrations (MIC) of 129 strains of genus Bacteroides, isolated from abscesses in pigs, for 13 different antimicrobial agents were determined by an agar-dilution method under anaerobic conditions. Clindamycin, the most active antibiotic tested, had a median MIC of 0.8 micrograms/ml. Penicillin G, talampicillin, minocycline, chloramphenicol, and cefoxitin also inhibited all isolates at lower concentrations. Some isolates of B pyogenes were susceptible to gentamicin (MIC, 0.4 micrograms/ml), erythromycin (MIC, 0.8 micrograms/ml), cephalexin (MIC, 0.8 micrograms/ml), and cefoxitin (MIC, 3.2 micrograms/ml). Erythromycin, at a concentration of 3.2 micrograms/ml, was active against 70% of B suis tested, but it was less active against the other Bacteroides species. Some strains tested were resistant to streptomycin and neomycin.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6524756&dopt=Abstract




Antimicrob Agents Chemother. 1984 Dec;26(6):837-40.
Enhancement of the in vitro activity of amphotericin B against Aspergillus spp. by tetracycline analogs.

Hughes CE, Harris C, Peterson LR, Gerding DN.

Strains of Aspergillus fumigatus, Aspergillus flavus, and Aspergillus niger were tested for in vitro susceptibility to amphotericin B alone and in combination with fixed concentrations of tetracycline, doxycycline, or minocycline, using buffered minimal essential medium in microtiter plates. Enhanced inhibitory activity was seen, especially with combinations of amphotericin B and minocycline. Synergistic activity between amphotericin B and minocycline was observed in each of five isolates of each species when tested in a checkerboard dilution scheme. Time-kill curves demonstrated killing an A. fumigatus isolated at concentrations of amphotericin B that were four- or eightfold lower in the presence of 5 or 15 micrograms of minocycline per ml than with amphotericin B alone. Of the tetracycline analogs tested, minocycline has the greatest activity against A. fumigatus, A. flavus, and A. niger conidia when potentiated by amphotericin B.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6524900&dopt=Abstract













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