Drugs online research references
J Antimicrob Chemother. 1984 Jun;13 Suppl C:17-22.
Treatment of severe staphylococcal infections with a rifampicin-minocycline association.
Clumeck N, Marcelis L, Amiri-Lamraski MH, Gordts B.
During an outbreak, 25 severely impaired patients (mean age 62) presented with severe infections due to Staphylococcus aureus resistant to oxacillin and aminoglycosides. All strains were isolated in pure culture and diagnostic procedures included transtracheal puncture and bone biopsy. Median MICs were: oxacillin 50 mg/l, gentamicin 12.5 mg/l, tetracycline 25 gm/l, vancomycin 0.195 mg/l, rifampicin 0.097 mg/l and minocycline 0.195 mg/l. All patients were treated with rifampicin (600 mg/day) and minocycline (200 mg or 400 mg/day) administered together intravenously or orally bid. Mean duration of treatment was 22 days (range 5 to 119). Overall results were 19/25 infections cured and one improved. Five were failures due mostly to emergence of Staph. aureus resistant to rifampicin. No side effects were noted. These preliminary results suggest that rifampicin plus minocycline may be useful in the treatment of severe infections due to multi-resistant Staph. aureus.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6469887&dopt=Abstract
Agents Actions. 1984 Jun;14(5-6):743-50.
Metal ion-tetracycline interactions in biological fluids. Part 3. Formation of mixed-metal ternary complexes of tetracycline, oxytetracycline, doxycycline and minocycline with calcium and magnesium, and their involvement in the bioavailability of these antibiotics in blood plasma.
Lambs L, Brion M, Berthon G.
The equilibria of the complexes formed separately by calcium and magnesium with tetracycline, oxytetracycline, doxycycline and minocycline were studied in the previous parts of this series. Computer simulations run on this occasion showed that the stoichiometry of these species do actually condition the bioavailability of the antibiotics in blood plasma during treatment, the fraction of free base being quite negligible with regard to the metal-bound one. The present paper completes this study with the investigation of the mixed-metal complexes given rise to by calcium and magnesium with the same antibiotics. Such ternary species have been proved to exist for tetracycline, oxytetracycline, and minocycline. Their involvement in the plasma distribution of these drugs is discussed, in relation with the potential abilities of the four tetracyclines to diffuse from plasma into tissue membranes.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6475671&dopt=Abstract
Dtsch Med Wochenschr. 1978 May 12;103(19):822-5.
[Minocycline in the treatment of respiratory tract infections (author's transl)]
[Article in German]
Sommerwerck D, Simon C, Friehoff J.
Minocycline concentrations in serum, saliva, sputum, pleural exudate and lung extracts after a single dose of 0.2 g (orally or intravenously) were measured on 32 patients with bronchial or lung disease. On the first day of treatment, concentrations in purulent sputum were five to ten times higher than in mucous sputum and saliva, after two hours they were one third, after three hours half the serum concentration (0.7 and 1.0 microgram/ml, respectively). After six hours the concentration was the same (1.6 microgram/ml). On the third day of treatment (after 0.2 g every 24 hours) concentrations in purulent sputum were higher than on the first day by 0.8 microgram/ml (after two hours) and by 0.95 microgram/ml (after three hours). After one-hour i.v. infusion of 0.2 g minocycline concentrations in mucous sputum and saliva rose more quickly on the first day than after oral administration. On the third day of treatment (after 0.1 g orally every 12 hours) pleural exudate level was almost as high as serum level. Minocycline concentration in lung extract on the third day of treatment--four, five and ten hours after the last dose--was 0.4 and 0.8 microgram/g, respectively (while serum concentration at the same time was 1.0-1.5 microgram/ml).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=648357&dopt=Abstract
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