Drugs online research references
Antimicrob Agents Chemother. 1984 Feb;25(2):165-7.
In vitro susceptibility of Nocardia asteroides to 25 antimicrobial agents.
Dewsnup DH, Wright DN.
Fifty-two clinical isolates of Nocardia asteroides were tested by agar dilution for their susceptibility to 25 antimicrobial agents. In general, susceptibility could not be predicted based on the antibiotic class tested. However, the beta-lactams, including third-generation cephalosporins, were generally ineffective (MIC for 90% of the organisms [MIC90], between 64 and greater than 256 micrograms/ml), whereas minocycline and doxycycline were generally effective (MIC90, 4 and 8 micrograms/ml, respectively). Cycloserine was not effective below 60 micrograms/ml. The MIC50 and MIC90 of sulfamethoxazole was 16 and 32 micrograms/ml, respectively, and that of trimethoprim varied widely (16 and greater than 256 micrograms/ml, respectively). Based on MIC90 data, only doxycycline, minocycline, sulfamethoxazole, and imipenem could be applied empirically.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6370125&dopt=Abstract
Br J Vener Dis. 1978 Apr;54(2):107-11.
Treatment and prognosis of non-specific genital infection.
Evans BA.
In a comparative trial minocycline was the best oral tetracycline compound for twice-daily administration in the treatment of non-specific urethritis. A review six months later showed that 29% of patients had needed further treatment, 35% of these more than one month after initial treatment and 12% between three and six months later. The history revealed no evidence of predisposition to non-specific urethritis among patients in whom relapse occurred. Multiple relapses were in the groups of patients who relapsed earliest. These cases proved more resistant to subsequent treatment, but all patients were eventually cured. The records of female contacts showed that 29% were symptomatic, 44% had an abnormal appearance of the cervix, but only 11% had inflammatory changes detected on cytological smear. A previous report was confirmed that there was no apparent benefit from the empirical treatment of contacts; possible reasons for this are given.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=638717&dopt=Abstract
Eur J Clin Microbiol. 1984 Oct;3(5):427-32.
Effects of antibiotics on adhesion of enterotoxigenic Escherichia coli strains.
Forestier C, Darfeuille-Michaud A, Joly B.
Subinhibitory concentrations of 28 antibiotics were tested for their effects on MRHA patterns of four enterotoxigenic Escherichia coli strains possessing colonization factor antigens CFA/I, CFA/II or CFA/III. Only penicillin G, oleandomycin, doxycycline and minocycline inhibited the haemagglutination pattern of three Escherichia coli strains with CFA/I and CFA/II when added to the medium culture at concentrations ranging from 1/2 to 1/50 of the MIC. At the same concentrations they also decreased the adhesion index of the four strains to human intestinal cells. However, neither the specific agglutination of bacterial cells with CFA antisera nor the production of CFAs was affected.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6389124&dopt=Abstract
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