Drugs online research references
Pathol Biol (Paris). 1983 May;31(5):413-8.
[Comparative activity of tetracycline, doxycycline and minocycline against Haemophilus]
[Article in French]
Dabernat H, Delmas C, Bauriaud R, Lareng MB.
A total of 90 isolates of Haemophilus were studied for susceptibility to tetracycline, doxycycline and minocycline. In vitro activity was determined by agar dilution method (MIC) and disk diffusion test. Disk diffusion tests were done on chocolate agar and on supplemented Mueller-Hinton agar. MICs rang from greater than or equal to 128 to 0,25, 32 to 0,5 and 32 to 0,25 micrograms/ml for tetracycline, doxycycline and minocycline respectively. Strains can be divided into tetracycline-sensitive strains which are inhibited by concentration less than or equal to 2 micrograms/ml and tetracycline-resistant strains inhibited by greater than or equal to 16 micrograms/ml. Sensitive strains are inhibited by 0,5-1 microgram/ml of doxycycline and 0,25-2 micrograms/ml of minocycline. Resistant strains are inhibited by concentrations from 2 to 32 micrograms/ml of doxycycline and from 0,5 to 32 micrograms/ml of minocycline. All but one resistant strains were inhibited by a concentration of less than or equal to 4 micrograms/ml of minocycline; all but two resistants strains were inhibited by doxycycline at a concentration greater than or equal to 4 micrograms/ml. The correlation coefficients are the following: for tetracycline, r = -0,95; for doxycycline r = -0,83 when disk diffusion test is done on supplemented Mueller-Hinton and r = -0,94 on chocolate agar; for minocycline r = -0,62 on supplemented Muller-Hinton and r = -0,75 on chocolate agar.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6353333&dopt=Abstract
Jpn J Antibiot. 1983 Aug;36(8):2103-8.
[Evaluation of in vitro antibacterial potencies of oral antibiotics against sputum isolates]
[Article in Japanese]
Yamada H, Nakanishi H, Yamaguchi M, Nagasawa Z.
Susceptibility of 162 sputum isolates to oral antibiotics was measured by an agar dilution method. The sputum isolates included S. pneumoniae 25 strains, S. aureus 30 strains, H. influenzae 37 strains, K. pneumoniae 51 strains and E. coli 19 strains. Minimal inhibitory concentration (MIC) values of cefaclor (CCL), cephalexin (CEX), ampicillin (ABPC) and minocycline (MINO) were measured for each strains. Eighty percent of S. pneumoniae strains were inhibited at 0.024 to 0.05 micrograms/ml of ABPC, 0.39 to 0.78 micrograms/ml of CCL, and 1.56 to 3.13 micrograms/ml of CEX and MINO. ABPC, CCL and CEX were considered to be effective clinically when they were used with the usual dosage. However, about 30% of strains were resistant to the usual dosage of orally administrated MINO. Eighty percent of S. aureus strains were inhibited at 0.20 to 0.39 microgram/ml of MINO and 3.13 to 6.25 micrograms/ml of the other 3 drugs. MINO is the most effective with the usual dosage. Twenty to 40% of strains showed resistance to CCL, CEX and ABPC. Eighty percent of H. influenzae strains were inhibited at 0.39 micrograms/ml of ABPC, 0.78 to 1.56 micrograms/ml of MINO, 3.13 micrograms/ml of CCL and 12.5 to 25 micrograms/ml of CEX. ABPC should be selected as the first choice antibiotic. However, there were 2 ABPC-resistant strains that were highly susceptible to CCL. Eighty percent of K. pneumoniae strains were inhibited at 0.39 to 0.78 micrograms/ml of CCL, 3.13 to 6.25 micrograms/ml of MINO and CEX, and 12.5 to 25 micrograms/ml of ABPC. CCL seemed to be only effective oral antibiotic for K. pneumoniae infection.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6361322&dopt=Abstract
umin.ac.jp
The in vitro activity of telithromycin (HMR3647), a new ketolide, against Mycoplasma pneumoniae was determined by the broth microdilution test using 41 clinical isolates obtained in Japan, as compared with those of five macrolides (erythromycin, clarithromycin, roxithromycin, azithromycin, and josamycin), minocycline, and levofloxacin. Telithromycin was less potent than azithromycin, but it was more active than four other macrolides, minocycline, and levofloxacin; its MICs at which 50 and 90% of the isolates tested were inhibited were both 0.00097 microg/ml, justifying clinical studies to determine its efficacy for treatment of M. pneumoniae.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10770785&dopt=Abstract
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