Drugs online research references
Chemotherapy. 1978;24(2):61-7.
Tri-monocycline: a minocycline complex for parenteral use. II. Blood levels, tissue contents and excretion of the antibiotic in animal experiments and after intravenous administration to humans.
Kahan IL.
Tri-minocycline prepared by mere dissolution of minocycline in an aqueous solution of a recommended complexing agent or using a preconstituted ready-for-use injection of the complex was administered intravenously to rabbits. Serum values were lower, tissue values higher than after injection of other tri-tetracyclines. Basing on these experimental quantitative data, single doses of tri-minocycline equivalent to 50-150 mg minocycline hydrochloride were administered once or twice daily to 13 adult patients during 1-6 days intravenously, without any serious or unusual side-effects. On average, 12% of the injected antibiotic was excreted in the urine, not later than 96 h after the last dose.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=620611&dopt=Abstract
Presse Med. 1983 Dec 10;12(45):2869-72.
[Role of Chlamydia trachomatis in the etiology of acute salpingitis. Value of the determination of IgG in 2 blood samples collected at 6 week intervals]
[Article in French]
Henry-Suchet J, Paris FX, Catalan A, Loffredo V, Diquelou JY, Ardoin P.
Cultures of specimens from the abdominal cavity (14) or the lower genital tract (11) were positive for Chlamydia trachomatis in 25 (22.7%) of 110 patients with a laparoscopic diagnosis of acute salpingitis. Microimmunofluorescence serodiagnosis showed positive IgG levels (greater than or equal to 1/64) in 35 patients (32%). Of the 34 patients in whom a second serodiagnosis was performed after 6 weeks, 20 (58%) had positive IgG levels (greater than or equal to 1/64) and 12 (35%) had a fourfold or more change in dilution. Thus, culture and serodiagnosis provided evidence of Chlamydia infection in 46% of the patient population. Forty-six patients were followed up for several months to evaluate the response to antibiotic therapy. Among tetracyclines, lymecycline was effective in 19/25 cases, doxycycline in 15/19 cases and minocycline in 2/4 cases. Switching to another tetracycline after failure of the first one usually gave satisfactory results.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6228863&dopt=Abstract
J Chemother. 2000 Feb;12(1):30-9.
Natural antibiotic susceptibility of Rahnella aquatilis and R. aquatilis-related strains.
Stock I, Gruger T, Wiedemann B.
Pharmaceutical Microbiology, University of Bonn, Germany.
A database is described of the natural susceptibilities of 70 Rahnella strains to 71 antibiotics. MIC values were determined by a microdilution procedure and evaluated by a table calculation program. Rahnella aquatilis and R. aquatilis-related strains were naturally resistant to amoxycillin, ticarcillin, fosfomycin and to antibiotics to which other species of Enterobacteriaceae are also intrinsically resistant, i.e. macrolides (except azithromycin), benzylpenicillin, oxacillin, rifampicin, fusidic acid, lincosamides and glycopeptides. Rahnella strains were also naturally resistant or intermediate to cefazolin, cefuroxime and loracarbef. All rahnellae were naturally sensitive or intermediate to doxycycline, minocycline, aminoglycosides, some penicillins and cephalosporins, carbapenems, aztreonam, quinolones, sulfamethoxazole, trimethoprim, cotrimoxazole, chloramphenicol and nitrofurantoin. Bimodal or broad MIC distributions were seen for several antibiotics, e.g. quinolones and cephalosporins. With the exception of quinolones no differences in natural antibiotic susceptibility were seen between reference strains of Rahnella genomovar 1 (n=6) and 2 (n=7). Reference strains of genomovar 1 were pyrase-positive and more susceptible to quinolones than reference strains of genomovar 2, which were pyrase-negative. By discrimination of all rahnellae in the pyrase-positive and pyrase-negative strains the MIC distributions for quinolones became smaller and unimodal. Under the conditions described pyrase might be a parameter to differentiate strains of Rahnella genomovars 1 and 2.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10768513&dopt=Abstract
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