Drugs online research references
J Antimicrob Chemother. 1985 Aug;16(2):199-204.
Effects of tetracyclines on experimental Legionella pneumophila infection in guinea-pigs.
Yoshida S, Mizuguchi Y, Ohta H, Ogawa M.
The activities of tetracycline, doxycycline and minocycline against Legionella pneumophila strain Philadelphia-1 were compared in vitro, in peritoneal macrophages and in-vivo experiments in guinea-pigs. Minocycline was the most effective in in-vitro minimum inhibitory concentration assays. In the assay measuring inhibitory effects of drugs on intracellular bacterial multiplication, minocycline and doxycycline were equally effective and tetracycline was the least effective of the three. In-vivo experiments were carried out using guinea-pigs infected intraperitoneally. From the analysis of cumulative survival rates, only minocycline had statistically significant effects. Doxycycline, however, did significantly prolong the infected animals' survival days. These data lend some support to the case reports showing that tetracycline derivatives are effective in the treatment of Legionnaires' disease.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4066557&dopt=Abstract
J Antibiot (Tokyo). 1977 Jul;30(7):593-6.
Effects of serum lipid content on the binding of minocycline.
Raff MJ, Summersgill JT, Fontana FJ, Barnwell PA, Waterman NG, Scharfenberger L.
Minocycline was added to normal and hyperlipemic serum samples in concentrations of 1 approximately 10 mcg/ml. These specimens had similar protein contents. Chemically extractable minocycline was quantitated fluorometrically. Hyperlipemic serum (cholesterol 480 mg/100 ml; triglycerides 321 mg/100 ml) yielded an average of 50% less minocycline than did normal serum (cholesterol 170 mg/100 ml; triglycerides 114 mg/100 ml). When ultrafiltrates of serum containing 6, 12 and 20 mcg/ml minocycline were assayed microbiologically, it was evident that variations in serum triglyceride and cholesterol levels did not alter the ratio of bound to free drug. Minocycline appears to be reversibly associated with, and/or soluble in, triglyceride-cholesterol components of serum.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=408318&dopt=Abstract
J Infect Dis. 1977 Aug;136(2):263-70.
Antifungal activity of four tetracycline analogues against Candida albicans in vitro: potentiation by amphotericin B.
Lew MA, Beckett KM, Levin MJ.
The antifungal activities of four tetracycline analogues in combination with amphotericin B (AmB) were determined against 20 strains of Candida albicans. When a microtiter checkerboard technique was used, minocycline (less than or equal to 10 microgram/ml) acted synergistically with AmB against all strains, whereas doxycycline had a reduced effect, and demeclocycline and tetracycline had no potentiating effect at this concentration. Killing-curve experiments with two strains of C. albicans demonstrated that the combination of minocycline and AmB produced a decrease in number of colony-forming units (cfu) of greater than 2 logs in 4 hr and a 4-log decrease in cfu in 24 hr at concentrations (minocycline, 0.64 microgram/ml; AmB, 0.1 microgram/ml) that were subinhibitory when each agent was used alone and that are readily achieved in human serum and body fluids with conventional doses. The killing-curve technique indicated that doxycycline had an intermediate degree of synergistic activity, whereas tetracycline had no synergistic activity at clinically relevant concentrations.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=408426&dopt=Abstract
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