Drugs online research references
Am J Vet Res. 1985 Jun;46(6):1316-8.
Compartmental and noncompartmental pharmacokinetic analyses of minocycline hydrochloride in the dog.
Wilson RC, Kitzman JV, Kemp DT, Goetsch DD.
Six adult dogs were given 5 mg of minocycline hydrochloride/kg of body weight IV. Pharmacokinetic evaluation of the serum drug concentration versus time data was performed, using the 2-compartment open model, the 3-compartment open model, and a noncompartmental model involving use of the statistical moment theory. All pharmacokinetic values except clearance were model independent. Minocycline half-life ranged between 6.48 and 7.24 hours; volume of distribution at steady state, between 1.859 +/- 0.368 and 2.001 +/- 0.468 L/kg; and clearance, between 3.195 +/- 0.618 and 3.424 +/- 0.684 ml/min/kg. These data are similar to those reported for oxytetracycline and indicate that the frequency of administration of the 2 tetracyclines should be the same. Three of the 6 dogs developed an adverse response to the IV injection of minocycline. Dog 1 developed urticaria and had initial serum drug concentrations of approximately 2 times the mean concentrations for the other dogs; values were not included in the pharmacokinetic analysis. Two other dogs had transient signs indicating cardiovascular depression or hypotension; their data were included. Due to the frequency of the unexpected reactions found in this study, it was concluded that dogs should not be given minocycline rapidly IV.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4026008&dopt=Abstract
Rev Epidemiol Sante Publique. 1985;33(2):142-9.
[The search for Yersinia enterocolitica in vegetables treated by a cold line in school cafeterias in Montpellier]
[Article in French]
Darbas H, Riviere M, Oberti J.
From 134 samples of raw or cooked vegetables taken in two points of a cold line we isolated 19 strains of Yersinia enterocolitica, 3 of Y. intermedia 3 of Y. kristensenii. None of them belongs to serotypes usually pathogenic for man. The raw vegetables are most contaminated. Y. kristensenii and Y. intermedia were isolated especially from samples of green salad. The used method was a cold enrichment at 4 degrees C followed by a potassium hydroxyde treatment. The activity of 16 antimicrobial drugs was studied by the disk diffusion test at 28 degrees C. All strains were sensitive to aminoglycosides, minocycline, colistine and cotrimoxazole. The results obtained with chloramphenicol and beta-lactam antibiotics vary in terms of species and/or biotypes.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4035045&dopt=Abstract
Am J Med Technol. 1979 Oct;45(10):835-9.
Susceptibility of streptococci to newer tetracyclines and cephalosporins and to other antimicrobial agents.
Freundlich LF, Zanfordino E, Rosenthal SL.
Two hundred and thirty-nine strains of Streptococcus including 71 strains of Group A, 81 strains of Group B, 69 strains of enterococci, and 18 strains of S. pneumoniae were tested against 12 antimicrobial agents using an agar dilution method. Cefamandole was the most active cephalosporin tested. Doxycycline and minocycline were more active than tetracycline, although the tetracyclines were considerably less inhibitory than the cephalosporins. Regression line analysis of zones of inhibition versus minimal inhibitory concentration values for tetracycline and minocycline showed the tetracycline disc to be unacceptable for predicting the susceptibility of the Group A Streptococcus to minocycline. Minimal inhibitory concentrations for clindamycin, erythromycin, chloramphenicol, nitrofurantoin, and spectinomycin are also given.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40435&dopt=Abstract
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