Drugs online research references
J Antimicrob Chemother. 1985 Nov;16(5):581-7.
Interaction of gentamicin, dibekacin, netilmicin and amikacin with various penicillins, cephalosporins, minocycline and new fluoro-quinolones against Enterobacteriaceae and Pseudomonas aeruginosa.
Van der Auwera P.
Thirty strains of Enterobacteriaceae and ten strains of Pseudomonas aeruginosa were selected to study the in-vitro activity of various combinations containing aminoglycosides, by the checkerboard method. The following aminoglycosides: gentamicin, dibekacin, netilmicin and amikacin were used in combination with each of the following: ampicillin, ticarcillin, piperacillin, cefazolin, cefuroxime, ceftazidime, norfloxacin, enoxacin and minocycline. Synergy was not a constant feature of beta-lactam+aminoglycoside combinations. Discrepancies occurred with the same strain submitted to combinations containing different aminoglycosides. The combinations containing new quinolones+aminoglycosides were usually additive, although occasionally synergy occurred. The combination minocycline+aminoglycoside was usually additive but partial antagonism (FIC or FBC index: 1 X 5- less than 2) occurred in 10 to 40% of the strains depending on the aminoglycoside. The combinations of beta-lactams with dibekacin or netilmicin most frequently produced partial or full synergy against strains of Ps. aeruginosa susceptible to all four aminoglycosides tested.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3935637&dopt=Abstract
Pathol Biol (Paris). 1985 Jun;33(5 Pt 2):577-80.
[Comparative activity of minocycline and doxycycline on mycoplasmas pathogenic for man]
[Article in French]
Bebear C, Cantet P, Renaudin H, Quentin C.
Susceptibility of Mycoplasma pneumoniae (10 strains), Mycoplasma hominis (20 strains) and Ureaplasma urealyticum (100 strains) to minocycline and doxycycline was studied in vitro. Minimal inhibitory concentrations were determined using an agar dilution method for M. pneumoniae and M. hominis and a metabolic inhibition test for U. urealyticum. M. pneumoniae strains were highly susceptible to minocycline and doxycycline (MIC less than or equal to 0.1 mg/l). Among M. hominis strains, 17 were susceptible (MIC less than or equal to 0.1 mg/l), whereas 3 were inhibited only by concentrations ranging from 4 to 16 mg/l. Among the 100 U. urealyticum strains, 95 were inhibited by 4 mg/l minocycline and 94 by 4 mg/l doxycycline. Both antibiotics exhibited similar activities against the three species (same ranges, same mode MICs).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3937130&dopt=Abstract
Int J Lepr Other Mycobact Dis. 1999 Dec;67(4):409-13.
Histopathological activity in paucibacillary leprosy patients after ROM therapy.
Ebenezer GJ, Job CK.
Department of Histopathology and Experimental Pathology, Schieffelin Leprosy Research and Training Center, Vellore District, Tamil Nadu, India.
Histopathological activity was assessed in the skin tissue of 13 skin-smear negative, borderline tuberculoid leprosy patients after administration of a single dose of ROM (rifampin 600 mg, ofloxacin 400 mg and minocycline 100 mg) therapy. Biopsies taken just before therapy showed Mycobacterium leprae to be present in eight cases. After 6 months, only three showed granulomatous lesions and others showed only resolving or inactive lesions. Acid-fast bacilli (AFB) persisted in the nerves of three cases. At the end of 12 months, granulomas persisted in 2 out of 13 (15%) patients. No bacilli, however, were detected in any of them at the end of 12 months. This study demonstrated that 12 months after a single dose of ROM granuloma cleared in 85% of the patients and AFB were absent in all of them.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10700915&dopt=Abstract
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