Drugs online research references
J Periodontol. 1985 Nov;56(11 Suppl):67-74.
Antibiotic susceptibilities of periodontal bacteria. In vitro susceptibilities to eight antimicrobial agents.
Walker CB, Pappas JD, Tyler KZ, Cohen S, Gordon JM.
In vitro susceptibilities of 369 to 966 bacterial isolates from periodontal lesions to eight antibiotics were determined by agar dilution technique as a means of determining which antimicrobial agents were inhibitory for bacteria frequently associated with destructive periodontal diseases. Although most bacteria were relatively susceptible to the penicillins, greater activity was generally noted with amoxicillin than with either penicillin or ampicillin with the exception of Selenomonas sputigena and Peptostreptococcus. Antibacterial activities obtained with minocycline were significantly higher than with tetracycline for Actinobacillus actinomycetemcomitans and Streptococcus but comparable for most other taxa. Clindamycin and metronidazole both demonstrated excellent activity against the anaerobic Gram-negative rods but were less effective against some of the capnophilic and facultative organisms. Eikenella corrodens was exceptionally resistant to both of these drugs; and A. actinomycetemcomitans was generally resistant to clindamycin but relatively susceptible to metronidazole. Erythromycin was considerably less active than the other antibiotics against the majority of the periodontal bacteria. No single antibiotic, at concentrations equivalent to those achieved in body fluids, was uniformly effective in inhibiting all bacteria currently implicated or suspected as etiologic agents of periodontal diseases.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3866054&dopt=Abstract
J Antimicrob Chemother. 1985 Jul;16(1):17-21.
Inhibition of beta-lactamase synthesis in Staphylococcus aureus by minocycline.
Chopra I, Anderson MA.
The effect of minocycline on beta-lactamase synthesis in Staphylococcus aureus was examined. Some inhibition of synthesis was detectable in organisms exposed to 0.015 mg minocycline/litre (0.15 of the single cell MIC) and complete inhibition was observed at 0.05 mg drug/litre (0.5 MIC). In contrast, total cell protein synthesis was less susceptible to inhibition by minocycline. Although synthesis of beta-lactamase was inhibited by low concentrations of minocycline, benzylpenicillin and minocycline failed to show synergy when tested in a variety of combinations against penicillinase producing staphylococci. In fact, benzyl-penicillin did not influence the minocycline MIC, and in the majority of cases the same pattern was exhibited by minocycline i.e. it did not generally alter the penicillin MIC. This is an example of true indifference whereby each antibiotic behaves as if the other were not present. The results presented here are discussed in relation to the possibility of therapeutic control of beta-lactamase producing organisms by suppressing the level of enzyme produced.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3876326&dopt=Abstract
Jpn J Antibiot. 1985 Jun;38(6):1685-92.
[In vitro antimicrobial activity of various antibiotics against Haemophilus influenzae isolated from clinical specimens in 1983]
[Article in Japanese]
Matsuo K, Uete T.
In vitro susceptibilities of 73 strains of Haemophilus influenzae isolated from clinical specimens in 1983 to various antibiotics were studied. The following antibiotics were evaluated; ampicillin (ABPC), piperacillin (PIPC), cefotaxime (CTX), cefoperazone (CPZ), ceftizoxime (CZX), cefmenoxime (CMX), latamoxef (LMOX), tetracycline (TC), doxycycline (DOXY), minocycline (MINO), chloramphenicol (CP) and erythromycin (EM). Susceptible strains to ABPC and PIPC with MICs less than 3 micrograms/ml were 80.3 and 84.1%, respectively. With this break point of MIC, all strains showed susceptibility to CPZ, CZX, and CMX, but resistant strains were observed in 1.5% against CTX and LMOX. Susceptible strains to TC, DOXY and MINO at MICs less than 2 micrograms/ml were 86.3, 80, and 87.7%, respectively. Those to CP at MICs less than or equal to 4 micrograms/ml and to EM at MICs less than or equal to 1 microgram/ml were 86.2 and 71.9%.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3876455&dopt=Abstract
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