Drugs online research references
J Chromatogr. 1987 Jul 29;400:253-61.
Improvement of chemical analysis of antibiotics. XII. Simultaneous analysis of seven tetracyclines in honey.
Oka H, Ikai Y, Kawamura N, Uno K, Yamada M, Harada K, Suzuki M.
Aichi Prefectural Institute of Public Health, Nagoya, Japan.
An analytical system for the simultaneous determination of residual oxytetracycline, tetracycline, chlortetracycline, doxycycline, methacycline, demethylchlortetracycline and minocycline in honey has been established by a combination of simple thin-layer chromatographic (TLC) and precise high-performance liquid chromatographic (HPLC) methods. In this system, screening by TLC can detect tetracyclines (TCs) at a level of 0.1 ppm in honey without the need for special equipment, and the quantitative method by HPLC can determine TCs with good recovery (83.7-99.6%) and coefficient variation (0.9-4.3%).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3667752&dopt=Abstract
Minerva Med. 1987 Oct 15;78(19):1443-7.
[295 cases of brucellosis treated with minocycline]
[Article in Italian]
Grasso E, Conversa P, Mondino P, Spirolazzi MP, Dalmasso G, Raineri G.
Divisione di Malattie Infettive, Ospedale Santa Crose, Cuneo U.S.S.L. n. 58.
295 cases of acute and subacute cases of brucellosis were treated with minocycline. It is concluded that because of its in vitro activity, its penetrability in macrophages and granulomas and its tolerance, minocycline is the antibiotic of choice for brucellosis.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3670688&dopt=Abstract
J Antibiot (Tokyo). 1987 Oct;40(10):1426-30.
In vitro and in vivo characterization of novel 8-methoxy derivatives of chlortetracycline.
Cacciapuoti A, Moss EL Jr, Menzel F Jr, Cramer CA, Weiss W, Loebenberg D, Hare RS, Miller GH.
Schering Corporation, Bloomfield, NJ 07003.
The in vitro activities of three new 8-methoxychlortetracyclines, Sch 36969, 33256 and 34164 were compared to tetracycline, minocycline and doxycycline. Against aerobic Gram-negative rods Sch 36969 had a geometric mean MIC (GMM) of 4.2 micrograms/ml, about 8-fold more potent than Sch 33256, and similar to all the other compounds. Sch 36969 also had good activity against methicillin-resistant (GMM, 0.21 micrograms/ml) and -susceptible Staphylococci (GMM, 0.14 micrograms/ml), Streptococci (GMM, 0.06 micrograms/ml), and most anaerobic bacteria (GMM, less than 0.5 micrograms/ml). In general, Sch 36969 was similar to, or more potent than, all the other compounds tested. Serum levels of Sch 36969 in squirrel monkeys were 4-fold lower (AUC, 4.5 micrograms.hours/ml) than those of chlortetracycline (AUC, 16.1 micrograms.hours/ml). In mouse protection tests (PD50s) against various strains of bacteria, Sch 36969 was similar in activity to tetracycline, but up to 6-fold less active than chlortetracycline. The structure activity relationships for these new chlortetracyclines are described.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3680008&dopt=Abstract
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