Drugs online research references
J Hyg Epidemiol Microbiol Immunol. 1986;30(2):185-93.
Methicillin-resistant Staphylococcus aureus (MRSA) in the German Democratic Republic. Incidence and strain-characteristics.
Witte W, Nguyen Van Dip, Dunnhaupt K.
In GDR methicillin-resistance strains of S. Aureus only occur in connection with nosocomial infections with a comparably low incidence (about 2%). They are not found in outpatients. For the detection of MRSA the test on nutrient medium L4 with addition of 5% NaCl has proved successful. All of the MRSA exhibit a rather unique pattern of strain-characteristics; they are nontypable by the basic-set-phages and show a reaction with the experimental phage A 994. The MRSA are multiple drug-resistant (generally penicillins, cephalosporins, isoxyzolylpenicillins, oxytetracycline, minocycline, streptomycin, erythromycin, lincomycin and additionally chloramphenicol and gentamycin, kanamycin, tobramycin). The genetical characterization and the plasmid-pattern analysis has shown that only resistance to chloramphenicol and in one case also to macrolides are determined by plasmids (MW 2.0 and 1.8 Megadalton). The determinants for the other resistance-characters are obviously located on the chromosome. Altogether these data indicate that the MRSA described are derivatives of a single-strain-clone.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3636387&dopt=Abstract
J Gen Microbiol. 1986 Jun;132 ( Pt 6):1723-8.
Detection of an integrated tetracycline resistance plasmid in the chromosome of methicillin-resistant Staphylococcus aureus.
Gillespie MT, May JW, Skurray RA.
The majority of multiresistant Staphylococcus aureus strains isolated in Australian hospitals since 1970 carry a chromosomally-encoded minocycline and tetracycline resistance determinant. By using DNA-DNA hybridization, some of these multiresistant strains were shown to possess also a tetracycline resistance plasmid, equivalent to pT181, integrated into a unique site in the chromosome. By relating the hybridization data to the map of pT181, the site of integration on this plasmid was established to be between the genes for replication and tetracycline resistance.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3643251&dopt=Abstract
Hinyokika Kiyo. 1987 May;33(5):719-23.
[Cytodiagnosis of Chlamydia trachomatis by the immunoperoxidase technic]
[Article in Japanese]
Toyoda K, Araki H.
Urological Clinic, Saiseikai Shigaken Hospital.
The PAP-immunocytochemistry using a monoclonal antibody against Chlamydia trachomatis was applied to male patients with clinically manifest urethritis and their female sex partners. In addition, serum levels of the antibody were determined by means of an ELISA system. Immunoperoxidase reactions were recognized on urethral scrapes in 53 (33%) out of 160 cases, and on endocervical specimens in 13 (59%) out of 22 sex partners of PAP-positive patients. In patients with gonococcal urethritis, an infection of C. trachomatis was revealed immunocytochemically in 11 (31%) out of 36 cases, and in 29 (46%) out of 62 cases with non-gonococcal urethritis. Following medication with 200 mg of minocycline or doxycycline per day, PAP staining became negative in 23 (66%) out of 35 cases. The levels of serum antibody against C. trachomatis were undetectable in 8 (26%) out of 29 PAP-positive cases, but positive in 7 (15%) out of 44 PAP-negative cases.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3661337&dopt=Abstract
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