Drugs online research references
J Hyg (Lond). 1978 Aug;81(1):131-8.
High and low level tetracycline resistance in Shigella sonnei.
Hawkins WA, Dale JW.
The results presented in this paper confirm the existence of two types of tetracycline resistance in Shigella sonnei. One group of strains had a high level of resistance to tetracycline and oxytetracyline, with a variable level of minocycline resistance. The second group had a lower level of tetracycline resistance and were sensitive to minocycline. After conjugation with E. coli K12 the selected E. coli transconjugants had the same levels of resistance as the parent Sh. sonnei strain, with one exception. Sh. sonnei 87 was resistant to a high level of tetracycline, but was able to transfer only low level resistance. It is suggested that Sh. sonnei 87 carriers two plasmids: pSU1, a conjugative plasmid conferring a low level of tetracycline resistance, and pSU2, a non-conjugative plasmid which confers a high level of resistance to tetracycline.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=357650&dopt=Abstract
Nippon Sanka Fujinka Gakkai Zasshi. 1987 Apr;39(4):525-30.
[A study of Chlamydia trachomatis infection in gynecological outpatients--direct specimen test and chlamydial IgG antibodies]
[Article in Japanese]
Kobayashi M, Hirakawa O, Tsuneoka H, Hashimoto K.
Among 226 outpatients, 30(13.3%) harboured Chlamydia trachomatis in the cervix. C. trachomatis was found in 15.1% of the patients with lower genital tract infection, 8.0% of pregnant women, 0.0% of sterile women, 14.3% of patients with pelvic inflammation and 88.9% of sexual partners respectively. The frequency of C.trachomatis infection in those 50 years old or more was 0.0%. One hundred and sixty-six women were also found to have titers of serum antibody to C.trachomatis. Serum IgG antibodies were found in 64 of 166(38.6%). Serum IgG antibodies were positive in 66.7% of the Chlamydia-positive women (20/30 subjects), whereas the positive rate was 31.0% in the Chlamydia-negative women (39/126 cases). In 40.0% of chlamydia positive patients, there was seen a significant rise in the number of paired sera. For C. trachomatis infection treatment with minocycline 100mg p.o. twice a day was effective (100%).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3585100&dopt=Abstract
Zentralbl Bakteriol Mikrobiol Hyg [A]. 1987 Feb;263(3):377-88.
Antibiotic therapy in early erythema migrans disease and related disorders.
Weber K, Neubert U, Thurmayr R.
Between December 1978 and July 1985, we used various antibiotics for the treatment of 97 adult patients with early erythema migrans disease (EMD). Six patients with borrelial lymphocytoma (BL) and 20 with acrodermatitis chronica atrophicans (ACA) were treated similarly. Follow-up was for a median of 20, 14, and 12 months, respectively. The erythema migrans and all associated symptoms resolved within a median of 3 weeks (0.5-18.4), BL within 7 weeks (4-16), and ACA partly or completely within several months. A Jarisch-Herxheimer (-like) reaction was observed in 8 patients with EMD. Fourteen patients with EMD and one with ACA developed an exacerbation of symptoms or new manifestations between the 2nd and 20th day, and 28 patients with EMD and one with ACA continued to have or acquired various symptoms greater than or equal to 3 weeks after initiation of therapy. Arthralgia, neurologic and constitutional symptoms, and in one instance a slight pulmonary interstitial edema developed in EMD. More severe initial illness was a risk factor for the development of later symptoms in EMD. Retreatment was more often necessary in ACA than in EMD. A patient with ACA had a recurrence after 5 1/2 years. IgG antibody titers rose at least fourfold in 5 patients with ACA and in 1 with EMD despite therapy. We tentatively recommend minocycline or high doses of parenteral penicillin for the treatment of these disorders.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3591091&dopt=Abstract
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