Drugs online research references
Zentralbl Bakteriol [Orig A]. 1977 Dec;239(4):527-34.
[Tetracyclines: bacteriostatic or bactericidal drugs? In vitro studies with rolitetracycline, minocycline and doxycycline (author's transl)]
[Article in German]
Daschner F.
Minimal bacteriostatic and minimal bactericidal concentrations of rolitetracycline, minocycline and doxycycline on 20 different E. coli serotypes and 16 staphylococcus aureus strains have been compared in bouillon and serum. In addition growth curves of all strains in bouillon and serum without and with antibiotics in concentrations corresponding to the minimal inhibitory concentration of each strain have been followed for 24 hours. In E. coli minimal bactericidal concentrations of all 3 tetracyclines in bouillon on average were only twice as high as the minimal bacteriostatic concentrations of the drugs, tested. Minimal bacteriostatic and bactericidal concentrations in serum were significantly lower than in bouillon. 27 out of 20 E. coli strains were inhibited by less than 0.012 microgram/ml. In staphylococci minimal bactericidal concentrations were substantially higher than the minimal bacteriostatic concentrations (on average at least four times higher). In E. coli addition of serum increased the antimicrobial activity of all tetracyclines tested. Growth curves in bouillon tended to show some bactericidal shape at 3, 7 and 24 hours following addition of the tetracyclines at minimal bacteriostatic concentrations. Bactericidal activity of tetracyclines at the MIC was substantially improved by addition of serum. This was not true for staphylococci in which neither minimal bactericidal and bacteriostatic concentrations nor growth curves could be significantly improved by addition of serum.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=345688&dopt=Abstract
Microbiol Immunol. 1986;30(5):445-50.
Antichlamydial activity of ofloxacin.
Hirai K, Une T.
The in vitro activity of ofloxacin, a new pyridone-carboxylic acid, against 11 strains of Chlamydia trachomatis and six strains of Chlamydia psittaci was determined. All test strains of both species were inhibited by 0.39 micrograms of ofloxacin per ml. The antichlamydial activity of ofloxacin was comparable to that of doxycycline and four- to eightfold less than that of minocycline. The results of this susceptibility test, coupled with those of previous pharmacokinetic analyses of ofloxacin, warrant further evaluation of its clinical usefulness against chlamydial infections.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3462450&dopt=Abstract
Arzneimittelforschung. 1987 Aug;37(8):950-3.
[Equilibriometric measurements of central vestibular dysregulation following administration of minocycline]
[Article in German]
Claussen CF, Schneider D, Claussen E.
Neurootologie, Universitats-HNO-Klinik Wurzburg.
An equilibriometric study has been performed on 20 healthy young women before and after the intake of 7 times 100 mg minocycline during 3 days. A systematic neurootological equilibriometry was performed analyzing the vestibular ocular, the vestibular spinal, the retino-ocular and the spontaneous nystagmus pathways. The results demonstrate that the tetracycline minocycline provokes a ponto-medullary liberation of the central vestibular regulating mechanisms. The central vestibular disinhibition could be exhibited by the monaurally elicited vestibular ocular nystagmus as well as by the radar image like cranio-corpography recordings of the head and body movements during a vestibular spinal stepping test. In parallel with these findings the participants of the study increasingly complained about vertigo of the rocking type, instability, malaise and wretching. Thus, the untoward side effects of a tetracycline like minocycline which is a frequent complaint of the patients, appears to be due to a central disinhibition of the vestibular equilibrium regulating mechanisms.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3499910&dopt=Abstract
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