Drugs online research references
J Pharm Sci. 1991 Dec;80(12):1177-9.
Instrumental color measurement: a method for judging the appearance of tablets.
Wirth M.
Department of Analytical Chemistry, Molndal, Sweden.
An instrumental method for the quantification of the color and the discoloration of tablets is presented. The results are not influenced by external factors and are more rapidly accessible compared with visual determination. Two of the measured parameters, lightness (delta L*) and yellowishness (delta b*) were found to reflect the changes in coloration observed in stability tests on white metoprolol tablets. Correlation studies between visual judgments and instrumental measurements are presented. The instrumental performance was carefully examined, and the results indicate that the employed instrument gives color parameters in the same range for tablet samples irrespective of whether the examined tablet surface has an engraving on it or not.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1815078&dopt=Abstract
Ophthalmic Res. 1985;17(1):49-53.
Are beta-adrenergic mechanisms involved in ocular hypotensive actions of adrenergic drugs?
Chiou GC, Watanabe K, McLaughlin MA, Liu HK.
Specific beta 1- and beta 2-adrenergic agonists and antagonists were studied for their effects on aqueous humor dynamics in a cat model. Tazolol (beta 1-agonist) reduced formation of aqueous humor more than outflow, while metoprolol (beta 1-antagonist) reduced outflow more than formation. Both salbutamol (beta 2-agonist) and butoxamine (beta 2-antagonist) inhibited aqueous humor formation and aqueous humor outflow to an equal extent. It is concluded that the adrenergic mechanism is functioning only slightly, if at all, in affecting the intraocular pressure. On the other hand, receptor binding experiments on iris-ciliary body showed clearly that there are 40-fold and 281-fold differences in binding affinity of D- and L-isomers of timolol and propranolol, respectively. These results indicate that the adrenergic receptor mechanism does exist in the eye tissues but that it does not control intraocular pressure significantly.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2858837&dopt=Abstract
Br J Pharmacol. 1997 Aug;121(8):1613-8.
Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat.
Jackson HC, Bearham MC, Hutchins LJ, Mazurkiewicz SE, Needham AM, Heal DJ.
Knoll Pharmaceuticals Research & Development, Nottingham.
1. Sibutramine is a novel 5-hydroxytryptamine (5-HT) and noradrenaline reuptake inhibitor (serotonin-noradrenaline reuptake inhibitor, SNRI) which is currently being developed as a treatment for obesity. Sibutramine has been shown to decrease food intake in the rat. In this study we have used a variety of monoamine receptor antagonists to examine the pharmacological mechanisms underlying sibutramine-induced hypophagia. 2. Individually-housed male Sprague-Dawley rats were maintained on reversed phase lighting with free access to food and water. Drugs were administered at 09 h 00 min and food intake was monitored over the following 8 h dark period. 3. Sibutramine (10 mg kg-1, p.o.) produced a significant decrease in food intake during the 8 h following drug administration. This hypophagic response was fully antagonized by the alpha 1-adrenoceptor antagonist, prazosin (0.3 and 1 mg kg-1, i.p.), and partially antagonized by the beta 1-adrenoceptor antagonist, metoprolol (3 and 10 mg kg-1, i.p.) and the 5-HT receptor antagonists, metergoline (non-selective; 0.3 mg kg-1, i.p.); ritanserin (5-HT2A/2C; 0.1 and 0.5 mg kg-1, i.p.) and SB200646 (5-HT2B/2C; 20 and 40 mg kg-1, p.o.). 4. By contrast, the alpha 2-adrenoceptor antagonist, RX821002 (0.3 and 1 mg kg-1, i.p.) and the beta 2-adrenoceptor antagonist, ICI 118,551 (3 and 10 mg kg-1, i.p.) did not reduce the decrease in food intake induced by sibutramine. 5. These results demonstrate that beta 1-adrenoceptors, 5-HT2A/2C-receptors and particularly alpha 1-adrenoceptors, are involved in the effects of sibutramine on food intake and are consistent with the hypothesis that sibutramine-induced hypophagia is related to its ability to inhibit the reuptake of both noradrenaline and 5-HT, with the subsequent activation of a variety of noradrenaline and 5-HT receptor systems.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9283694&dopt=Abstract
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