Drugs online research references
Drug Nutr Interact. 1985;3(3):165-72.
Effects of hypercholesterolemia on beta adrenoceptors in the rabbit heart.
Mokler CM, Abdel-Aziz MT, Heric E.
Hypercholesterolemia has been shown to cause an increased vascular reactivity to catecholamines, but the mechanisms leading to greater smooth muscle responsiveness are not clear. Since membrane lipids are associated with receptors, a change in receptor structure and affinity for agonists could have been responsible. This study examined pharmacologic characteristics of cardiac beta adrenoceptors in isolated hearts from rabbits which had been fed a high cholesterol diet for 4, 6, or 8 weeks. Parameters measured were the spontaneous rate changes of the isolated right atrium and changes in refractory period of the isolated, perfused ventricles as these were induced by cumulative doses of the beta receptor agonist isoproterenol. The efficacy of a specific beta-one adrenoceptor blocking drug, metoprolol, in blocking these effects of isoproterenol was also evaluated. The rate and refractory period responses to isoproterenol and the blocking effectiveness of metoprolol were the same in all groups, as were the maximum responses induced by the agonist. It thus appears that hypercholesterolemia does not alter membrane beta adrenoceptor responsiveness in rabbit hearts.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2992901&dopt=Abstract
Vutr Boles. 1989;28(1):31-6.
[Long-term treatment of hypertension with a selective beta-1-blockader without sympathomimetic activity. II. Changes in the structure and function of the left ventricle]
[Article in Bulgarian]
Sirakova V, Penkov N, Kaponov Kh.
The effect of the 6 months long treatment with the Hungarian selective beta-1-blocker Betaloc (Metoprolol) on the structure and function of the left ventricle was studied in 30 hypertensive patients--II stage (with echocardiographically proved left ventricular hypertrophy) by means of simultaneous recording of M-type echocardiogram, ACG, PCG and ECG. The telediastolic thickness of the septum and the posterior wall and the left ventricular muscular mass decrease at the end of the 6-th month (p less than 0.0001). The telesystolic dimension and volume decrease (p less than 0.0001) in the 6-th month without changes in the telediastolic dimension and volume (p greater than 0.32). The shortening fraction and the ejection fraction increase (p less than 0.0001), Vcf increases insignificantly (p greater than 0.05). The isovolumetric relaxation shortens (p less than 0.0001), the active suction period lengthens (p less than 0.0001) as well as the fast filling period (p less than 0.0027). By controlling the arterial pressure and suppressing the sympathetic stimulation of the heart the prolonged Betaloc treatment leads to reversion of the hypertrophy and improves the left ventricular function.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2525846&dopt=Abstract
Respiration. 1980;39(3):139-43.
Ventilatory response to hypercapnia in normal subjects after propranolol, metoprolol and oxprenolol.
Folgering H, Braakhekke J.
Steady state ventilatory response curves to CO2 were taken in 8 normal subjects in control situations and taking clinical doses of propranolol, oxprenolol and metoprolol in a double-blind crossover design. Furthermore, the expiratory peak flow was measured. No effect was found of any of the beta-blockers on the resting ventilatory parameters, the sensitivity to CO2 or the peak flow values.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6773123&dopt=Abstract
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