Drugs online research references
J Med Chem. 1981 Apr;24(4):451-4.
Adrenoceptor blocking agents. Compounds related to metoprolol.
Lovgren K, Hedberg A, Nilsson JL.
A group of compounds, structurally related to metoprolol, in which the aromatic nucleus is formally moved stepwise away from the ethanolamine side chain, has been studied as adrenergic agonists and antagonists. All the compounds were active on the adrenergic receptors and showed similar affinity for the receptor regardless of the distance between the aromatic nucleus and the ethanolamine moiety. An ethereal oxygen may be of importance for the affinity to the receptor but this oxygen may not necessarily have to be located as an OCH2 group between the aromatic ring and the ethanolamine chain of the beta-blocker molecule.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6115060&dopt=Abstract
J Chromatogr A. 1997 Feb 21;762(1-2):235-41.
On-line column-switching high-performance liquid chromatography analysis of cardiovascular drugs in serum with automated sample clean-up and zone-cutting technique to perform chiral separation.
Mangani F, Luck G, Fraudeau C, Verette E.
Gilson Medical Electronics (France) S.A., Villiers-le-Bel, France.
A selective and highly reproducible, multi-column HPLC method is described for the analysis of the following cardiovascular drugs: lidocaine, pindolol, metoprolol, oxprenolol, diltiazem and verapamil, in serum. Column-switching devices are employed in combination with advanced separation media technologies for the automated analysis of samples containing complex matrices. The method consists of on-line sample clean-up using a restricted access sorbent, HPLC analysis of the drugs on a microsphere non-porous silica RP-18 column, and front-cutting to perform the chiral separation of pindolol enantiomers on a second HPLC system. Simultaneous control of the two HPLC systems and data analysis is achieved from a single centralized software. The R.S.D. values of the peak areas for spiked serum are less than 1% for metoprolol and oxprenolol, 2-5% for lidocaine, diltiazem and verapamil, and 1.2 and 2.4% for the two pindolol enantiomers. Recoveries, limits of detection and linearities are provided.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9098982&dopt=Abstract
J Chromatogr. 1979 Apr 1;171:357-62.
Atenolol determination by high-performance liquid chromatography and fluorescence detection.
Yee YG, Rubin P, Blaschke TF.
A high-performance liquid chromatographic procedure using a fluorescence detector for the analysis of atenolol in plasma and whole blood is described. It employs a simple and rapid method of preparation. Atenolol and metoprolol as the internal standard are chromatographed as ion pairs with heptanesulfonic acid. The method is sensitive and reproducible with accurate detection at concentrations as low as 2 ng/ml in whole blood and plasma, and a coefficient of variation of 4.7% over the range 2 ng/ml to 1000 ng/ml.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=546856&dopt=Abstract
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