Drugs online research references
Diabete Metab. 1993 Jan-Feb;19(1):44-51.
Effect of metformin treatment on glucose tolerance and glomerulosclerosis in KK mice.
Reddi AS, Jyothirmayi GN.
Department of Medicine, UMDNJ-New Jersey Medical School, Newark 07103.
Non-obese KK mice, aged 90-100 days, demonstrating an abnormal tolerance to glucose, hyperinsulinaemia with insulin resistance and glomerulosclerosis were treated with either water (control N = 10) or metformin (N = 15), a biguanide, orally at a concentration of 50 mg/kg twice daily for 16 weeks. Oral glucose tolerance was performed at 7 weeks. Only 10 of 15 metformin-treated mice (responders) improved their oral glucose tolerance. The remaining 5 mice (non-responders) did not improve their tolerance to the oral glucose load. A repeated oral glucose tolerance test at 16 weeks showed similar results. Blood lactate and insulin levels were similar in all 3 groups of mice. At sacrifice, responders had significantly less glomerulosclerosis compared to control mice. No difference in the incidence of glomerulosclerosis was found between control mice and non-responders. The data suggest that chronic metformin treatment improves glucose tolerance in 70% of KK mice without increasing blood lactate or insulin levels. This improvement in glycaemic control is associated with a lesser incidence of glomerulosclerosis in KK mice.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8504884&dopt=Abstract
Helv Paediatr Acta. 1977 Apr;31(6):473-80.
Effect of biguanide treatment in obese children.
Lutjens A, Smit JL.
In seven children of normal weight and in nine obese children (more than 30% overweight) from 8 to 14 years of age, blood glucose and insulin levels were estimated. The obese children were then treated with dimethylbiguanide (Metformin-HCl) during 3 months. After this period the tests were repeated. It is shown that a significant reduction of the insulin values, insulinogen indices and weight occurred after this treatment.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=853001&dopt=Abstract
Akush Ginekol (Sofiia). 2001;40(3):25-7.
[Our experience in the treatment of polycystic ovary syndrome with Metformin]
[Article in Bulgarian]
Mitkov M, Pekhlivanov B, Simeonov S, Velchev G.
Basing on the key role of the hyperinsulinemia in the etiopathogenesis of the Polycystic ovary syndrome, the authors treat the affected women with Metformin. In an 1 year prospective study, including 30 women, they assess the effect of the application of Metformin in relation to some indexes--BMI, WHR, IRI, LH, LH/FSH ratio. After analysing the results, it is reported for a decrease in the absolute values of BMI, WHR and a tendency for redistribution of the adipose tissue from visceral to gynoid type. They report for a statistical reliability in the decrease of LH and LH/FSH ratio. The level of IRI decreases pointedly at every stage of the study. 28 of the patients influence favourably in one or other degree, regarding the menstrual cycles. A good results is also reported in reference to Arterial Hypertension. According to the authors, Mtformin is a good alternative in the treatment of the PCOS.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11785362&dopt=Abstract
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