Drugs online research references
Vutr Boles. 1980;19(4):21-4.
[Treatment of diabetics with metformin]
[Article in Bulgarian]
Tikholov K, Kalpazanova N, Peshev P, Kostov M, Kusinikov V.
After a brief survey of the mechanism of biquanides treatment and their indications and contraindications with the peroral treatment of diabetes mellitus, the adverse effects of that treatment are stressed upon, manifested mainly in lactacidosis. The latter is indicated to be most frequently found during the treatment with tenformin, rarely -- with buformin and most rarely and in a lighter form -- with metformin. That uneven effect of biquanide preparations is associated with a certain difference in their pharmacodynamics and pharmacokinetics. On the other hand -- those adverse effects result most frequently from unproper treatment carried outnot observing the indications and particularly the contraindications and surpassing the therapeutic doses. Very good results are reported, that were obtained by the authors, in the treatment with metform of 70 diabetic patients with insulin-independent type of diabetes and body overweight, that failed to respond to the treatment with a reducing diet or a diet and sulfurea preparations and resistant to insulin. Indications for that treatment are presented as well as the necessity of strict observation of the contraindications for its administration.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7415155&dopt=Abstract
Clin Chem. 1981 Mar;27(3):434-6.
Rapid liquid-chromatographic determination of metformin in plasma and urine.
Charles BG, Jacobsen NW, Ravenscroft PJ.
We describe an analysis for metformin in plasma and urine by use of cation-exchange "high-performance" liquid chromatography. The assay requires only 0.5 mL of sample and involves pretreatment with trichloroacetic acid containing an internal standard (1-propylbiguanide), followed by centrifugation and injection into the chromatograph. The column eluent is monitored at 230 nm. Metformin and 1-propylbiguanide give retention times of 8 and 10 min, respectively. Within-day and between-day precision (CV) for the assay of plasma containing 2 mg (1.2 X 10(-5) mol) of metformin hydrochloride per liter was 3.6 and 3.9%, respectively. Similar precision was obtained for urine. The limit of detection is about 0.1 mg (6.0 X 10(-7) mol) of metformin hydrochloride per liter. Several commonly used drugs, including other oral hypoglycemic agents, do not interfere with this method.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7471394&dopt=Abstract
Acta Med Austriaca. 1978;5(3):91-5.
[Effect of biguanide therapy on lactate metabolism during graded submaximal ergometric testing]
[Article in German]
Pilger E, Schmid P, Goebel R.
Diabetic patients were subjected to exercise testing before and after a short antidiabetic therapy with phenformin, buformin or metformin. Primarily, changes of lactate and of the acid base balance, were analyzed. After therapy with biguanides all 24 patients had increased lactate levels before and after physical strain. Phenformin showed the greatest influence on the lactate metabolism. Metformin the least.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=752221&dopt=Abstract
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