Drugs online research references
Drugs Exp Clin Res. 1989;15(11-12):565-70.
Effects of metformin therapy on plasma amino acid pattern in patients with maturity-onset diabetes.
Marchetti P, Masiello P, Benzi L, Cecchetti P, Fierabracci V, Giannarelli R, Gregorio F, Brunetti P, Navalesi R.
Department of Replacement Problems, University of Perugia, Italy.
Plasma amino acid concentrations and metformin levels were measured by high-performance liquid chromatography in a group of diabetic patients on therapy with the biguanide drug. Diabetic patients treated with metformin showed higher concentrations of plasma glutamate, asparagine, alanine, methionine and tryptophan, and lower levels of ornithine in comparison with normal subjects, and higher levels of alanine when compared to diet-treated diabetic patients. No correlation emerged between amino acid concentrations and metformin dose or plasma concentration. It is concluded that besides the various metabolic abnormalities that are known to occur during metformin treatment, patients on therapy with metformin also show multiple changes of plasma amino acid pattern.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2637797&dopt=Abstract
Horm Metab Res. 1989 Feb;21(2):81-3.
The influence of Guar gum on absorption of metformin from the gut in healthy volunteers.
Gin H, Orgerie MB, Aubertin J.
Clinique Medicale et des maladies infectieuses, Hopital Pellegrin, Bordeaux, France.
Dietary fibre and biproducts of some vegetable extracts (Guar etc.) are advocated to reduce postprandial hyperglycaemia but there is some evidence that these may disturb the absorption kinetics of orally administered drugs. The effect of Guar gum on the digestive absorption of metformin was tested in 6 healthy subjects given 1700 mg of metformin with a standardised meal. Metformin blood levels showed that when given together with Guar there was a reduction in the absorption rate over the first 6 hours. These findings suggest that combination therapy may diminish the anti-hyperglycaemic action of metformin.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2722133&dopt=Abstract
Q J Med. 1988 Feb;66(250):137-46.
Impaired beta-cell responses improve when fasting blood glucose concentration is reduced in non-insulin-dependent diabetes.
Ferner RE, Rawlins MD, Alberti KG.
Wolfson Unit of Clinical Pharmacology, Royal Victoria Infirmary, Newcastle upon Tyne.
Pancreatic beta-cell responses to a controlled intravenous glucose stimulus in 18 untreated non-insulin-dependent diabetic patients were compared with those in seven healthy control subjects. The patients' first-and second-phase responses were only 10 to 20 per cent of those of the normal subjects. However, when normal subjects had been hyperglycaemic for two hours, their first-phase responses were similar to those of the patients. Six patients were subsequently treated by diet alone, six by diet and tolbutamide and six by diet and metformin. There was no improvement in first-phase responses after treatment, but second-phase responses doubled. Improved responses were seen with all treatments, and correlated with the fall in fasting blood glucose concentration during treatment. This study supports the view that hyperglycaemia impairs beta-cell function and suggests that first-phase responses are more sensitive to hyperglycaemia than second-phase responses.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3051084&dopt=Abstract
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