Drugs online research references
Biosci Rep. 1989 Jun;9(3):347-50.
Interaction between diazepam and oral antidiabetic agents on serum glucose, insulin and chromium levels in rats.
al-Ahmed FA, el-Denshary ES, Zaki M, el-Sawaf HA, Abu-Jayyab AR.
Department of Pharmacology, College of Pharmacy, King Saudi University, Riyadh, Kingdom of Saudi Arabia.
This study was undertaken to investigate the effect of diazepam in the presence and absence of glibenclamide, metformin or their combination on serum levels of glucose, insulin and chromium in rats. Results indicated that diazepam (10 mg/kg i.p.) induced marked hyperglycaemic effects in hyperglycaemic rats. This effect was associated with significant reductions in serum chromium levels and insignificant reduction in serum insulin levels. Diazepam-induced hyperglycaemia was counteracted by concurrent administration of glibenclamide (5 mg/kg orally), metformin (500 mg/kg orally) or their combination. The effect of diazepam on serum chromium level was counteracted partially by administration of glibenclamide and augmented in the presence of metformin or its combination with glibenclamide. It is concluded that the diazepam-induced hyperglycaemia, as well as the hypoglycaemic effect of glibenclamide, might be related to changes in serum chromium levels.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2505873&dopt=Abstract
Diabete Metab. 1989 May-Jun;15(3):111-7.
Metformin potentiates B-cell response to high glucose: an in vitro study on isolated perfused pancreas from normal rats.
Gregorio F, Filipponi P, Ambrosi F, Cristallini S, Marchetti P, Calafiore R, Navalesi R, Brunetti P.
Istituti di Clinica Medica Ie, Universita di Perugia, Italy.
This study investigated the effects of metformin on pancreatic A-B- and D-cell functions using the isolated perfused rat pancreas model. The lactate output rate following metformin infusion was also monitored. Metformin was infused at the low "therapeutic" concentration of 1.5 micrograms/ml and its effects were evaluated in three different glycaemic conditions: during a basal infusion of 4.44 mM glucose, during a moderate increase to 8.88 mM of glucose concentration, and finally during a higher 16.66 mM glycaemic stimulus. Basal insulin secretion and B-cell release during the lower hyperglycaemic stimulus were unaffected by metformin infusion. On the contrary, the drug significantly enhanced insulin response to 16.66 mM glucose, particularly by increasing the second phase of hormone release. Glucagon and somatostatin releases during metformin infusion were similar to the secretory pattern observed in the control experiments both in the basal condition and in the presence of the two different hyperglycaemic stimuli. Finally metformin did not modify the lactate output rate from perfused pancreas, irrespective of the different glycaemic conditions employed. Therefore our data suggest--at least in rats, in in vitro experiments but above all in the presence of markedly elevated hyperglycaemic conditions--that metformin may influence the glucose stimulatory effect on B-cell activity.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2569414&dopt=Abstract
Pol Arch Med Wewn. 1989 Mar;81(3):183-8.
[Somatostatin-like activity (SLI) in the blood during metformin treatment of obese patients with diabetes mellitus type 2]
[Article in Polish]
Lawecki J, Stryjek-Kaminska D, Schusdziarra V.
Plasma somatostatin-like activity (SLI) was measured in obese women with type 2 diabetes in fasting condition and after a test meal (714 kcal: 27% carbohydrates, 8% protein, 73% fat). The tests were done twice: first, after a week of dietetic treatment and then 7 days of metformin administration, 1.5 g a day. Blood glucose and insulin concentration (IRI) were also followed throughout the test. The plasma SLI on fasting and after the test meal, before and after treatment with metformin did not show any significant differences. Blood glucose was lower in the fasting state significantly and serum insulin showed a tendency to decrease at the end of the test. These findings contradict the hypothesis of a possible role of somatostatin in peripheral blood in the enteric effect of metformin. The local (paracrine?) action of SLI secreted after metformin administration cannot be excluded.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2576469&dopt=Abstract
online pharmacies ||
Hair Million herbal formula for hair loss and hair growth ||
Amoxicillin ||
Tramadol ||
Paxil ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Zithromax ||
online pharmacy ||
Antibiotics and prescription medications online literature ||
Antibiotics