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J Cardiovasc Pharmacol. 1987;9 Suppl 3:S61-5.
Long-term monotherapy with lisinopril in renovascular hypertension.

Fyhrquist F, Gronhagen-Riska C, Tikkanen I, Junggren IL.

Eleven patients (five women and six men), aged 24-60 years, were treated with the angiotensin-converting enzyme (ACE) inhibitor, lisinopril, with a once-daily dose as the only antihypertensive treatment. Renal artery stenosis was unilateral in eight patients and bilateral in the remaining three. Fibromuscular dysplasia was present in seven patients, and renal arteriosclerotic narrowing was present in the remaining four. All completed a 6-month treatment and went on to a long-term treatment program for a final 24 months, now completed by five patients. Mean pretreatment blood pressure, 187 +/- 19/112 +/- 5 mm Hg (systolic/diastolic; mean +/- SD), was reduced to 148/87 following the drug titration period (1 week), and the same antihypertensive control was maintained throughout the study. Plasma concentration of angiotensin II, aldosterone, and serum ACE activity were effectively reduced for at least 24 h following drug administration. Serum concentrations of lisinopril varied individually and rose in two patients with moderate renal failure. Renal function was well maintained, and control renography revealed no worsening of renal artery stenosis or renal function. The drug was well tolerated without side effects other than cough in one patient. We conclude that lisinopril monotherapy is highly effective in renovascular hypertension. Drug safety was demonstrated by the lack of serious side effects.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2442555&dopt=Abstract




J Hum Hypertens. 1989 Jun;3 Suppl 1:163-7.
Safety and efficacy of lisinopril in elderly patients with mild to moderate hypertension.

Marlier R, Vandepapeliere P, De Vriese G.

Bijloke Ziekenhuis, Gent, Belgium.

The safety and efficacy of once-daily lisinopril was assessed in an 8-week open-label study of 24 elderly patients with mild to moderate hypertension. Following withdrawal of all previous antihypertensive treatment, including diuretics, lisinopril treatment was started at a dose of 5 mg, increasing to a maximum of 40 mg once daily as required. Treatment provided effective 24-h BP control in all patients, most of whom required a daily dose of 20-40 mg, and cardiothoracic index decreased significantly, indicating a favourable effect on left ventricular volumes. There were no significant ECG alterations and no major side effects occurred. It is concluded that lisinopril 5 mg is a safe starting dose for elderly patients who are not on diuretics, and that once-daily lisinopril monotherapy reduces BP safety without affecting heart rate.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2550639&dopt=Abstract




Clin Cardiol. 1993 Feb;16(2):129-32.
Efficacy of once-daily lisinopril monotherapy in systemic hypertension.

Hwang YS, Yen HW.

Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China.

Lisinopril is a new, long-acting angiotensin-converting enzyme inhibitor formulated for once-daily treatment of hypertension. This study assessed the 24-h efficacy and tolerability of lisinopril in Chinese patients with mild to moderate hypertension of World Health Organization Stages I to II. A total of 30 patients aged 30 to 60 years (mean 47 +/- 9) entered a 2-week washout period. All patients had ambulatory diastolic blood pressure (BP) > 90 mmHg and were given active treatment with lisinopril for 4 to 7 weeks. The dose of lisinopril was titrated from 10 to 40 mg daily (at 8-9 A.M.). In each patient, 24-h ambulatory blood pressure (BP) monitoring (SpaceLabs 90202) was performed twice, once before and once following treatment. Mean 24-hour systolic/diastolic BPs after lisinopril were significantly decreased compared with baseline values (132 +/- 12/86 +/- 7 vs. 150 +/- 11/98 +/- 7 mmHg; p < 0.0005/0.0005). The average dose of lisinopril was 14.5 +/- 5 mg daily after a titration period of 5 weeks of treatment. Mean daytime (6 A.M. to 6 P.M.) BP decreased from 152 +/- 11/100 +/- 8 to 134 +/- 12/87 +/- 8 mmHg (p < 0.0005/0.0005) and nighttime (6 P.M. to 6 A.M.) BP from 147 +/- 14/95 +/- 9 to 128 +/- 14/83 +/- 8 mmHg (p < 0.0005/0.0005). BP reduction was more pronounced during the night. Before treatment, the circadian variation showed a peak BP at 11 A.M. and nadir at 3 P.M. After treatment, significant BP reduction (p < 0.0005/0.0005) was seen throughout the 24-h period.(ABSTRACT TRUNCATED AT 250 WORDS)

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8382123&dopt=Abstract












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