Drugs online research references
Eur J Pharmacol. 1992 Mar 3;212(2-3):279-81.
Nitric oxide participation in renal hemodynamic effect of angiotensin converting enzyme inhibitor lisinopril.
Hajj-ali AF, Zimmerman BG.
Department of Pharmacology, University of Minnesota, Minneapolis 55455.
Nitric oxide (NO) contribution to the renal hemodynamic effect of lisinopril was assessed in anesthetized rabbits. NG-Nitro-L-arginine (NArg), slightly decreased renal blood flow following vehicle. Also, NArg reversed partially the increase in renal blood flow caused by DuP 753, and almost completely reversed the effect of lisinopril. The results suggest that NO plays an important role in the renal hemodynamic effect of lisinopril, more so than its contribution to the effect of DuP 753.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1376274&dopt=Abstract
Clin Sci (Lond). 1987 Mar;72(3):387-9.
Lack of angiotensin I accumulation after converting enzyme blockade by enalapril or lisinopril in man.
Nussberger J, Brunner DB, Waeber B, Biollaz J, Brunner HR.
In nine normal volunteers, a series of five venous blood samples was obtained before and up to 24 h after converting enzyme inhibition by a single oral dose of enalapril or lisinopril. Plasma renin activity and blood angiotensin I were measured. A close linear relationship was found between the increase in plasma renin activity and the increase in blood angiotensin I. The linear correlation between plasma renin activity and blood angiotensin I remained after converting enzyme inhibition. Thus, the rise in angiotensin I after inhibition of the conversion of angiotensin I to angiotensin II is due to an enhanced release of renin rather than to accumulation of angiotensin I.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3028701&dopt=Abstract
Am J Physiol. 1994 Apr;266(4 Pt 2):R1273-9.
Mechanisms of hypertension in transgenic rats expressing the mouse Ren-2 gene.
Moriguchi A, Brosnihan KB, Kumagai H, Ganten D, Ferrario CM.
Hypertension Center, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157.
Transgenic (TG) rats carrying the mouse Ren-2 gene (Ren-2d)27 are a newly established monogenetic model in hypertension research. To gain an insight into the mechanisms of this form of hypertension we determined the effects of a 13-day therapy with losartan (10 mg/kg) or lisinopril (20 mg/kg) on the blood pressure (BP) and plasma levels of angiotensin (ANG) peptides of mature female TG hypertensive and Sprague-Dawley (SD) rats. The contribution of endothelium-derived nitric oxide (NO) to the maintenance of their hypertension and the response to therapy was evaluated by systemic injection of either NG-monomethyl-L-arginine (L-NMMA) or endothelin-1. Hypertension in TG rats was associated with decreased plasma ANG I, no differences in plasma ANG II, and plasma ANG-(1-7) near the detectable level. Lisinopril lowered BP more than losartan in both TG hypertensive and normotensive controls. In both strains, the chronic fall in BP produced by lisinopril was accompanied by significant increases in plasma ANG I and ANG-(1-7), while losartan augmented plasma ANG I and ANG II in both strains and plasma ANG-(1-7) in TG rats. Inhibition of NO synthase reversed the fall in BP produced by either lisinopril or losartan in SD controls. In contrast, administration of L-NMMA to TG rats given the same therapy did not. The transient endothelium-mediated relaxing phase of the depressor response to systemic injections of endothelin-1 was attenuated by losartan and lisinopril in TG rats. These studies indicate that hypertension in female TG rats is mediated by the RAS.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8184972&dopt=Abstract
online pharmacies ||
Hair Million herbal formula for hair loss and hair growth ||
Amoxicillin ||
Tramadol ||
Paxil ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Zithromax ||
online pharmacy ||
Antibiotics and prescription medications online literature ||
Antibiotics