Drugs online research references
Yao Xue Xue Bao. 1995;30(6):476-80.
[Pharmacokinetics and bioavailability of glipizide capsules]
[Article in Chinese]
Chen QC, Yang CQ, Chao CH, Ma YG, Li XN, Chen WL.
Zhongshan Hospital of Shanghai.
The pharmacokinetics and bioavailability of glipizide were studied in 8 healthy male volunteers after a single oral dose of 5 mg in capsule or in tablet. The plasma levels of glipizide were assayed by high performance liquid chromatography. The concentration--time curves of both preparations were fitted to a one compartment model. The pharmacokinetic parameters of glipizide in capsule and in tablet were shown in tables 2 and 3. The relative bioavailability of the capsule was 109.9% compared with the tablet.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7572185&dopt=Abstract
Acta Diabetol. 1995 Mar;32(1):64-8.
Standardized procedure for the assay and identification of hypoglycemic sulfonylureas in human plasma.
Sener A, Akkan AG, Malaisse WJ.
Laboratory of Experimental Medicine, Erasmus Medical School, Brussels Free University, Belgium.
A standardized procedure for the assay and identification of hypoglycemic sulfonylureas in plasma is presented. External standards and plasma extracts containing glibenclamide, gliquidone, glipizide, or gliclazide were examined by high-performance liquid chromatography. The four sulfonylureas could be identified and measured with a precision of 5%-7% and a limit of detection close to 1-2 ng in injected external standards and 10-40 ng/ml in plasma samples. This method is suitable to study the pharmacokinetics of hypoglycemic sulfonylureas, for blood drug monitoring in diabetic patients, for diagnostic purposes in factitious hypoglycemia, and in cases relevant to forensic medicine.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7612921&dopt=Abstract
J Appl Physiol. 1995 Jun;78(6):2062-9.
Role of G proteins in the vasodilator response to endothelin isopeptides in vivo.
Lippton HL, Hao Q, Erdemli O, Hyman A.
Department of Surgery, Tulane Medical School, Louisiana State University Medical School, New Orleans 70112, USA.
The purpose of the present study was to determine the influence of pertussis toxin (PTX) on the pulmonary and systemic vasodilator responses to endothelin (ET) isopeptides in the intact cat under conditions of constant pulmonary blood flow and left atrial pressure. When pulmonary vasomotor tone was actively increased by an intralobar arterial infusion of U-46619, intralobar arterial bolus injections of ET-1, ET-2, and ET-3 decreased lobar arterial pressure and systemic vascular resistance in a dose-related manner. The vasodilator responses to ET-1 and ET-2 in the cat lung were abolished by PTX pretreatment, whereas PTX pretreatment did not alter the pulmonary vasodilator response to ET-3 and cromakalim, a specific ATP-sensitive potassium (KATP) channel activator, and the systemic vasodilator responses to all ET isopeptides studied. Glipizide, an inhibitor of KATP channels, inhibited the pulmonary vasodilator responses to ET-1, ET-2, and ET-3, whereas the systemic vasodilator responses to these isopeptides were not changed. The present data are the first to provide a functional correlate in vivo suggesting the existence of different signal transduction mechanisms for two pulmonary vascular ET receptor subtypes, ETA-like that is PTX sensitive and has greater sensitivity to ET-1 and ET-2 (than to ET-3) and ETc-like that is PTX insensitive and has sensitivity to ET-3 (than to ET-1 and ET-2). However, both ET-receptor subtypes promote vasodilation in the adult pulmonary vascular bed by activating KATP channels.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7665400&dopt=Abstract
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