Drugs online research references
Arch Intern Med. 1982 Aug;142(8):1498-1500.
Lipid metabolism in non-insulin-dependent diabetes mellitus: effect of glipizide therapy.
Greenfield MS, Doberne L, Rosenthal M, Vreman HJ, Reaven GM.
Plasma lipid concentration and lipoprotein composition were studied before and after several months of glipizide treatment in 23 patients with non-insulin-dependent diabetes mellitus. The mean (+/- SEM) plasma glucose level fell 87 mg/dL, and the fall in plasma glucose concentration was correlated with a reduction in plasma triglyceride, very low-density lipoprotein triglyceride, cholesterol, and low-density lipoprotein cholesterol levels. Furthermore, there was a statistically significant increase in the plasma high-density lipoprotein cholesterol to total cholesterol ratio. Thus, improved diabetic control in patients treated with glipizide with non-insulin-dependent diabetes mellitus leads to changes in lipoprotein metabolism thought to be beneficial in terms of known cardiovascular risk factors.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7103631&dopt=Abstract
Clin Pharmacokinet. 1982 Jul-Aug;7(4):363-72.
Bioavailability, pharmacokinetics and effects of glipizide in type 2 diabetics.
Wahlin-Boll E, Almer LO, Melander A.
The pharmacokinetics of glipizide were studied in 6 type 2 diabetics following single dose intravenous administration of Img, and oral administration of 2.5 mg as a solution, a 2.5 mg tablet and a 5 mg tablet. The serum concentrations of the drug were measured by high pressure liquid chromatography. Glipizide showed a rapid distribution fitting a 2-compartment model. The distribution volume at assumed distribution equilibrium was small (10L), and the elimination half-life was short (2 to 4 hours). Gastrointestinal bioavailability was 100%. In one patient, glipizide absorption from tablets was retarded due to delayed tablet disintegration and drug dissolution. Each dose of glipizide reduced blood glucose levels rapidly in all patients.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7116738&dopt=Abstract
J Pharmacol. 1980 Oct-Dec;11(4):463-72.
[Kinetic aspects of the glipizide-induced hypoglycemia in the dog (author's transl)]
[Article in French]
Blayac JP, Ribes G, Valette JF, Loubatieres-Mariani MM.
The study of the kinetics of hypoglycemia induced by glipizide (second generation hypoglycemic sulfonamide) was carried out on the normal conscious dog. 1. In a first series of experiments glipizide was given intravenously at the dose of 0.1 mg .kg-1. The hypoglycemic effect of the drug occurred rapidly and reached a maximum at the 30th minute. This maximum effect did not much vary from one animal to another. The hypoglycemic action persisted at least 7 hours after the injection, and at the 24th hour blood glucose level returned practically to the initial values. 2. The kinetics of hypoglycemia after per os administration were studied when glipizide was given either in solid form preparation or in solution form. Glipizide given per os in powder form at the dose of 0.1 mg . kg-1 induced a kinetics of hypoglycemia which varied from one animal to another. The hypoglycemic effect which appeared within 1 to 4 hours after administration, reached its maximum within 2 to 6 hours; it ranged from -6 p. 100 to -52 p. 100. A tenfold higher dose (1 mg . kg-1) produced a hypoglycemia which occurred more rapidly, with less dispersion in the intensity of the response. When glipizide was given at the dose of 0.1 mg . kg-1 in solution form, it can be noted that in all cases hypoglycemia occurred earlier than after administration in powder form at the same dose, while the dispersion in the maximum effect is still considerable. These results lay stress once again on the importance of the form of administration on the kinetics of hypoglycemia and on its intensity.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7206734&dopt=Abstract
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